[(2S)-3-(6-amino-9H-purin-9-yl)-2-hydroxypropyl] 2-O-benzyl-α-D-xylopyranoside

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Chemical Name:[(2S)-3-(6-amino-9H-purin-9-yl)-2-hydroxypropyl] 2-O-benzyl-α-D-xylopyranoside
CAS No.:418766-97-9
Molecular Formula:C₂₀H₂₅N₅O₆
Molecular Weight:431.448
Hs Code.:

Synonyms:[(2S)-3-(6-amino-9H-purin-9-yl)-2-hydroxypropyl] 2-O-benzyl-α-D-xylopyranoside

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Chemical Property of [(2S)-3-(6-amino-9H-purin-9-yl)-2-hydroxypropyl] 2-O-benzyl-α-D-xylopyranoside

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Technology Process of [(2S)-3-(6-amino-9H-purin-9-yl)-2-hydroxypropyl] 2-O-benzyl-α-D-xylopyranoside

There total 8 articles about [(2S)-3-(6-amino-9H-purin-9-yl)-2-hydroxypropyl] 2-O-benzyl-α-D-xylopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 418766-94-6
[(2S)-2-hydroxy-3-(6-amino-9H-purin-9-yl)propyl] 3,4-di-O-benzoyl-2-O-benzyl-α-D-xylopyranoside

: 418766-97-9
[(2S)-3-(6-amino-9H-purin-9-yl)-2-hydroxypropyl] 2-O-benzyl-α-D-xylopyranoside

Guidance literature:: With sodium methylate; In methanol;
DOI:10.1016/S0968-0896(01)00329-7

Reference yield:

: 196859-39-9
allyl 3,4-di-O-benzoyl-2-O-benzyl-α-D-xylopyranoside

: 418766-97-9
[(2S)-3-(6-amino-9H-purin-9-yl)-2-hydroxypropyl] 2-O-benzyl-α-D-xylopyranoside

Guidance literature:: Multi-step reaction with 3 steps

1.1: TFA / 10 percent Pd/C / dioxane; H₂O / 20 h / Heating

1.2: K₂CO₃; Cl₃CCN / CH₂Cl₂ / 12 h / 20 °C

1.3: 4 Angstroem MS; TMSOTf / CH₂Cl₂ / 0.75 h / -20 °C

2.1: NaH / dimethylformamide / 1.5 h / 80 °C

2.2: dimethylformamide / 3 h / 80 °C

3.1: 95 percent / MeONa / methanol

With sodium methylate; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00329-7