2-phenyl-2-((7R)-1,4-dioxaspiro[4.5]decan-7-yl)acetaldehyde

Base Information

Chemical Name:2-phenyl-2-((7R)-1,4-dioxaspiro[4.5]decan-7-yl)acetaldehyde
CAS No.:1351983-74-8
Molecular Formula:C₁₆H₂₀O₃
Molecular Weight:260.333
Hs Code.:

Synonyms:2-phenyl-2-((7R)-1,4-dioxaspiro[4.5]decan-7-yl)acetaldehyde

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Chemical Property of 2-phenyl-2-((7R)-1,4-dioxaspiro[4.5]decan-7-yl)acetaldehyde

Chemical Property:

Purity/Quality:

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Technology Process of 2-phenyl-2-((7R)-1,4-dioxaspiro[4.5]decan-7-yl)acetaldehyde

There total 4 articles about 2-phenyl-2-((7R)-1,4-dioxaspiro[4.5]decan-7-yl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351983-73-7
2-phenyl-2-((7R)-1,4-dioxaspiro[4.5]decan-7-yl)ethanol

: 1351983-74-8
2-phenyl-2-((7R)-1,4-dioxaspiro[4.5]decan-7-yl)acetaldehyde

Guidance literature:: With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide; In water; ethyl acetate; at 4 - 8 ℃; for 0.75h; Temperature; Concentration; Time; Large scale;

Reference yield:

: 1351983-70-4
methyl 2-phenyl-2-((2R)-1,4-dioxaspiro[4.5]decan-7-yl)-acetate

: 1351983-74-8
2-phenyl-2-((7R)-1,4-dioxaspiro[4.5]decan-7-yl)acetaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran; toluene / 1.5 h / 5 - 20 °C / Large scale

1.2: 0.67 h / 13 - 22 °C / Large scale

1.3: 0.33 h / 10 - 20 °C / Large scale

2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide; sodium hypochlorite / ethyl acetate; water / 0.75 h / 4 - 8 °C / Large scale

With sodium hypochlorite; lithium aluminium tetrahydride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide; In tetrahydrofuran; water; ethyl acetate; toluene;

Reference yield:

: 619329-97-4
(S)-2-(1,4-dioxa-spiro[4.5]dec-7-yl)-malonic acid dimethyl ester

: 1351983-74-8
2-phenyl-2-((7R)-1,4-dioxaspiro[4.5]decan-7-yl)acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium chloride; water / N,N-dimethyl acetamide / 5 h / 120 - 136 °C / Large scale

2.1: n-hexyllithium; diisopropylamine / toluene; hexane / 0.92 h / 5 - 10 °C / Large scale

2.2: 3 h / 10 - 20 °C / Inert atmosphere; Large scale

3.1: lithium aluminium tetrahydride / tetrahydrofuran; toluene / 1.5 h / 5 - 20 °C / Large scale

3.2: 0.67 h / 13 - 22 °C / Large scale

3.3: 0.33 h / 10 - 20 °C / Large scale

4.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide; sodium hypochlorite / ethyl acetate; water / 0.75 h / 4 - 8 °C / Large scale

With sodium hypochlorite; lithium aluminium tetrahydride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; n-hexyllithium; sodium hydrogencarbonate; diisopropylamine; lithium chloride; potassium bromide; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; water; ethyl acetate; toluene;