4-{(E)-[3,5-difluoro-4-(methoxymethoxy)]vinyl}-2,6-dimethylnitrobenzene

Base Information

Chemical Name:4-{(E)-[3,5-difluoro-4-(methoxymethoxy)]vinyl}-2,6-dimethylnitrobenzene
CAS No.:1313376-40-7
Molecular Formula:C₁₈H₁₇F₂NO₄
Molecular Weight:349.334
Hs Code.:

Synonyms:4-{(E)-[3,5-difluoro-4-(methoxymethoxy)]vinyl}-2,6-dimethylnitrobenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-{(E)-[3,5-difluoro-4-(methoxymethoxy)]vinyl}-2,6-dimethylnitrobenzene

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Technology Process of 4-{(E)-[3,5-difluoro-4-(methoxymethoxy)]vinyl}-2,6-dimethylnitrobenzene

There total 7 articles about 4-{(E)-[3,5-difluoro-4-(methoxymethoxy)]vinyl}-2,6-dimethylnitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 864513-22-4
diethyl (3,5-dimethyl-4-nitrobenzyl)phosphonate

: 1313376-39-4
3,5-difluoro-4-(methoxymethoxy)benzaldehyde

: 1313376-40-7
4-{(E)-[3,5-difluoro-4-(methoxymethoxy)]vinyl}-2,6-dimethylnitrobenzene

Guidance literature:: diethyl (3,5-dimethyl-4-nitrobenzyl)phosphonate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.166667h;

3,5-difluoro-4-(methoxymethoxy)benzaldehyde; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h;
DOI:10.1039/c1cc11681a

Reference yield:

: 18515-22-5
(3,5-dimethyl-4-nitrophenyl)methanol

: 1313376-40-7
4-{(E)-[3,5-difluoro-4-(methoxymethoxy)]vinyl}-2,6-dimethylnitrobenzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus tribromide / 2 h / 20 °C

2.1: tetra-(n-butyl)ammonium iodide / 4.5 h / 120 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

3.2: 2 h / 20 °C

With phosphorus tribromide; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; mineral oil;
DOI:10.1039/c1cc11681a

Reference yield:

: 40113-65-3
5-(bromomethyl)-1,3-dimethyl-2-nitrobenzene

: 1313376-40-7
4-{(E)-[3,5-difluoro-4-(methoxymethoxy)]vinyl}-2,6-dimethylnitrobenzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetra-(n-butyl)ammonium iodide / 4.5 h / 120 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

2.2: 2 h / 20 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; mineral oil;
DOI:10.1039/c1cc11681a