Technology Process of C17H12NP
There total 3 articles about C17H12NP which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-bromo-3-(2-bromophenyl)pyridine;
With
tert.-butyl lithium;
In
diethyl ether; pentane;
at -78 ℃;
for 1h;
Inert atmosphere;
Dichlorophenylphosphine;
In
diethyl ether; pentane;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1021/ic200951x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran; water / 72 h / Inert atmosphere; Reflux
2.1: phosphorus tribromide / 40 h / 140 °C / Inert atmosphere
3.1: tert.-butyl lithium / diethyl ether; pentane / 1 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); tert.-butyl lithium; phosphorus tribromide; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; diethyl ether; water; pentane;
1.1: Suzuki-Miyaura coupling;
DOI:10.1021/ic200951x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran; water / 72 h / Inert atmosphere; Reflux
2.1: phosphorus tribromide / 40 h / 140 °C / Inert atmosphere
3.1: tert.-butyl lithium / diethyl ether; pentane / 1 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); tert.-butyl lithium; phosphorus tribromide; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; diethyl ether; water; pentane;
1.1: Suzuki-Miyaura coupling;
DOI:10.1021/ic200951x
