N¹-benzyloxycarbonyl-N²-(N^α-t-butoxycarbonyl-N^g-tosylarginyl)-1,2-ethanediamine

Base Information

• Chemical Name: N¹-benzyloxycarbonyl-N²-(N^α-t-butoxycarbonyl-N^g-tosylarginyl)-1,2-ethanediamine
• CAS No.: 205874-86-8
• Molecular Formula: C₂₈H₄₀N₆O₇S
• Molecular Weight: 604.728

Synonyms:N¹-benzyloxycarbonyl-N²-(N^α-t-butoxycarbonyl-N^g-tosylarginyl)-1,2-ethanediamine

Chemical Property of N¹-benzyloxycarbonyl-N²-(N^α-t-butoxycarbonyl-N^g-tosylarginyl)-1,2-ethanediamine

Chemical Property:

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Technology Process of N¹-benzyloxycarbonyl-N²-(N^α-t-butoxycarbonyl-N^g-tosylarginyl)-1,2-ethanediamine

There total 1 articles about N¹-benzyloxycarbonyl-N²-(N^α-t-butoxycarbonyl-N^g-tosylarginyl)-1,2-ethanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.5%

Boc-Arg(Tos)-OH (13836-37-8) + benzyl N-(2-aminoethyl)carbamate hydrochloride (18807-71-1) → N1-benzyloxycarbonyl-N2-(Nα-t-butoxycarbonyl-Ng-tosylarginyl)-1,2-ethanediamine (205874-86-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1246/bcsj.71.699

Reference yield:

N1-benzyloxycarbonyl-N2-(Nα-t-butoxycarbonyl-Ng-tosylarginyl)-1,2-ethanediamine (205874-86-8) → H-Arg(Ts)-Eda-Z

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1246/bcsj.71.699

Reference yield:

N1-benzyloxycarbonyl-N2-(Nα-t-butoxycarbonyl-Ng-tosylarginyl)-1,2-ethanediamine (205874-86-8) → N1-benzyloxycarbonyl-N2-(Nα-benzyloxycarbonyl-Nα-methyl-O-benzyltyrosyl-Ng-tosylarginyl)-1,2-ethanediamine (205874-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / CH₂Cl₂ / 20 °C

2: 656 mg / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, 1-hydroxybenzotriazole / dimethylformamide / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: deprotection / 2: Acylation;

DOI:10.1246/bcsj.71.699

upstream raw materials:

Boc-Arg(Tos)-OH

benzyl N-(2-aminoethyl)carbamate hydrochloride

Downstream raw materials:

N¹-benzyloxycarbonyl-N²-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)-1,2-ethanediamine

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