N-benzyl-2-methyl-2-vinylazetidine

Base Information

• Chemical Name: N-benzyl-2-methyl-2-vinylazetidine
• CAS No.: 1198423-01-6
• Molecular Formula: C₁₃H₁₇N
• Molecular Weight: 187.285
• Mol file: 1198423-01-6.mol

Synonyms:N-benzyl-2-methyl-2-vinylazetidine

Chemical Property of N-benzyl-2-methyl-2-vinylazetidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-benzyl-2-methyl-2-vinylazetidine

There total 4 articles about N-benzyl-2-methyl-2-vinylazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

1-benzyl-4-methyl-4-vinyl-2-azetidinone → N-benzyl-2-methyl-2-vinylazetidine (1198423-01-6)

Guidance literature:

With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 50 ℃; Inert atmosphere;

DOI:10.1002/anie.201100612

Reference yield:

N-benzyl-2-methyl-2-formylazetidine (1198423-23-2) + Methylenetriphenylphosphorane (19493-09-5) → N-benzyl-2-methyl-2-vinylazetidine (1198423-01-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 20h;

DOI:10.1021/ol902299p

Reference yield:

4-methyl-4-vinylazetidin-2-one (20012-94-6) → N-benzyl-2-methyl-2-vinylazetidine (1198423-01-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / Cooling with ice

1.2: 0 - 20 °C

2.1: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 50 °C / Inert atmosphere

With aluminum (III) chloride; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; mineral oil;

DOI:10.1002/anie.201100612

upstream raw materials:

N-benzyl-2-methyl-2-formylazetidine

Methylenetriphenylphosphorane

4-methyl-4-vinylazetidin-2-one

benzyl bromide

Downstream raw materials:

C₂₁H₂₄N₂O₃S

C₂₁H₂₄N₂O₃S

1-benzyl-4-methyl-1 ,2,3,6-tetrahydropyridine