(R)-N'-((2-(4-chloro-N-(4-methoxybenzyl)phenylsulfonamido)-4-methylpentanoyl)oxy)acetimidamide

Base Information

• Chemical Name: (R)-N'-((2-(4-chloro-N-(4-methoxybenzyl)phenylsulfonamido)-4-methylpentanoyl)oxy)acetimidamide
• CAS No.: 1408001-52-4
• Molecular Formula: C₂₂H₂₈ClN₃O₅S
• Molecular Weight: 482
• Mol file: 1408001-52-4.mol

Synonyms:(R)-N'-((2-(4-chloro-N-(4-methoxybenzyl)phenylsulfonamido)-4-methylpentanoyl)oxy)acetimidamide

Chemical Property of (R)-N'-((2-(4-chloro-N-(4-methoxybenzyl)phenylsulfonamido)-4-methylpentanoyl)oxy)acetimidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N'-((2-(4-chloro-N-(4-methoxybenzyl)phenylsulfonamido)-4-methylpentanoyl)oxy)acetimidamide

There total 1 articles about (R)-N'-((2-(4-chloro-N-(4-methoxybenzyl)phenylsulfonamido)-4-methylpentanoyl)oxy)acetimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

(R)-2-(4-chloro-N-(-4-methoxybenzyl)phenylsulfonamido)-4-methylpentanoic acid (1408001-51-3) + acetamide oxime (118493-85-9,117771-39-8,1141922-26-0,1429624-21-4) → (R)-N'-((2-(4-chloro-N-(4-methoxybenzyl)phenylsulfonamido)-4-methylpentanoyl)oxy)acetimidamide (1408001-52-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2012.09.057

Reference yield: 78.0%

(R)-N'-((2-(4-chloro-N-(4-methoxybenzyl)phenylsulfonamido)-4-methylpentanoyl)oxy)acetimidamide (1408001-52-4) → (R)-4-chloro-N-(4-methoxybenzyl)-N-(3-methyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)butyl)benzenesulfonamide (1408001-36-4)

Guidance literature:

In toluene; for 16h; Reflux;

DOI:10.1016/j.bmcl.2012.09.057

upstream raw materials:

(R)-2-(4-chloro-N-(-4-methoxybenzyl)phenylsulfonamido)-4-methylpentanoic acid

acetamide oxime

Downstream raw materials:

(R)-4-chloro-N-(4-methoxybenzyl)-N-(3-methyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)butyl)benzenesulfonamide