(3aS,4S,6R,6aR)-6-{6-[2-(1-Benzyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide

Base Information

Chemical Name:(3aS,4S,6R,6aR)-6-{6-[2-(1-Benzyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide
CAS No.:1053700-69-8
Molecular Formula:C₃₃H₃₅N₇O₄
Molecular Weight:593.685
Hs Code.:

(3aS,4S,6R,6aR)-6-{6-[2-(1-Benzyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide

Synonyms:(3aS,4S,6R,6aR)-6-{6-[2-(1-Benzyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide

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Chemical Property of (3aS,4S,6R,6aR)-6-{6-[2-(1-Benzyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide

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Technology Process of (3aS,4S,6R,6aR)-6-{6-[2-(1-Benzyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide

There total 5 articles about (3aS,4S,6R,6aR)-6-{6-[2-(1-Benzyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 1053700-69-8
(3aS,4S,6R,6aR)-6-{6-[2-(1-Benzyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / K₂CO₃ / dimethylformamide / 2 h / Heating

2: 71 percent / AcONH₄ / 0.5 h / Heating

3: 58 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

4: Et₃N / ethanol / 6 h / Heating

With lithium aluminium tetrahydride; ammonium acetate; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00051a007

Reference yield:

: 10511-51-0
1-Benzylindole-3-carboxaldehyde

: 1053700-69-8
(3aS,4S,6R,6aR)-6-{6-[2-(1-Benzyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / AcONH₄ / 0.5 h / Heating

2: 58 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

3: Et₃N / ethanol / 6 h / Heating

With lithium aluminium tetrahydride; ammonium acetate; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00051a007

Reference yield:

: 100-44-7
benzyl chloride

: 1053700-69-8
(3aS,4S,6R,6aR)-6-{6-[2-(1-Benzyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / K₂CO₃ / dimethylformamide / 2 h / Heating

2: 71 percent / AcONH₄ / 0.5 h / Heating

3: 58 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

4: Et₃N / ethanol / 6 h / Heating

With lithium aluminium tetrahydride; ammonium acetate; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00051a007