afatinib fumarate

Base Information

Chemical Name:afatinib fumarate
CAS No.:1398312-22-5
Molecular Formula:C₄H₄O₄*C₂₄H₂₅ClFN₅O₃
Molecular Weight:602.019
Hs Code.:

Synonyms:afatinib fumarate

Suppliers and Price of afatinib fumarate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of afatinib fumarate

Chemical Property:

Purity/Quality:

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Technology Process of afatinib fumarate

There total 2 articles about afatinib fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.7%

: 850140-72-6,1680184-59-1,945553-91-3,439081-17-1,439081-18-2
afatinib

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 1398312-22-5,850140-73-7
afatinib fumarate

Guidance literature:: In ethanol; at 20 - 70 ℃; Product distribution / selectivity;

Reference yield:

: 618061-76-0
(S)-diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate

: 1398312-22-5,850140-73-7
afatinib fumarate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / water / 20 - 30 °C / Inert atmosphere

1.2: 2.5 h / -15 - 20 °C / Inert atmosphere

2.1: ethanol / 20 - 70 °C

With hydrogenchloride; In ethanol; water;