benzyl (S)-1-(methyl(2-methylphenyl)carbamoyl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:benzyl (S)-1-(methyl(2-methylphenyl)carbamoyl)pyrrolidine-2-carboxylate
CAS No.:1462366-69-3
Molecular Formula:C₂₁H₂₄N₂O₃
Molecular Weight:352.433
Hs Code.:

Synonyms:benzyl (S)-1-(methyl(2-methylphenyl)carbamoyl)pyrrolidine-2-carboxylate

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Chemical Property of benzyl (S)-1-(methyl(2-methylphenyl)carbamoyl)pyrrolidine-2-carboxylate

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Technology Process of benzyl (S)-1-(methyl(2-methylphenyl)carbamoyl)pyrrolidine-2-carboxylate

There total 1 articles about benzyl (S)-1-(methyl(2-methylphenyl)carbamoyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 52209-63-9
N-methyl-N-(2-methylphenyl)carbamoyl chloride

: 16652-71-4
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

: 1462366-69-3
benzyl (S)-1-(methyl(2-methylphenyl)carbamoyl)pyrrolidine-2-carboxylate

Guidance literature:: benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride; With triethylamine; In 1,2-dimethoxyethane; for 0.166667h; Inert atmosphere;

N-methyl-N-(2-methylphenyl)carbamoyl chloride; With dmap; In 1,2-dimethoxyethane; for 20h; Inert atmosphere; Reflux;
DOI:10.1039/c3cc46193a

Reference yield: 99.0%

: 1462366-69-3
benzyl (S)-1-(methyl(2-methylphenyl)carbamoyl)pyrrolidine-2-carboxylate

: 1462366-70-6
(S)-1-(methyl(2-methylphenyl)carbamoyl)pyrrolidine-2-carboxylic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1039/c3cc46193a

Reference yield:

: 1462366-69-3
benzyl (S)-1-(methyl(2-methylphenyl)carbamoyl)pyrrolidine-2-carboxylate

: 2-methyl-7a-(2-methylphenyl)tetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 h / 20 °C / Inert atmosphere

2: lithium chloride; lithium diisopropyl amide / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1039/c3cc46193a