Technology Process of (S)-methyl 9-hydroxy-10-tosyloxydecanoate
There total 3 articles about (S)-methyl 9-hydroxy-10-tosyloxydecanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1002/ejoc.201201442
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfuric acid / 1 h / 20 °C / Inert atmosphere
2: potassium carbonate; (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); potassium hexacyanoferrate(III); potassium osmate / tert-butyl alcohol; water / 2.5 h / 20 °C / Inert atmosphere
3: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
With
dmap; potassium osmate; (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); sulfuric acid; potassium carbonate; triethylamine; potassium hexacyanoferrate(III);
In
dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/ejoc.201201442
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate; (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); potassium hexacyanoferrate(III); potassium osmate / tert-butyl alcohol; water / 2.5 h / 20 °C / Inert atmosphere
2: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
With
dmap; potassium osmate; (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); potassium carbonate; triethylamine; potassium hexacyanoferrate(III);
In
dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/ejoc.201201442
