1-Phenyl-8-benzyl-1,3,8-triazaspiro[4.5]deca-2-ene-4-one

Base Information

Chemical Name:1-Phenyl-8-benzyl-1,3,8-triazaspiro[4.5]deca-2-ene-4-one
CAS No.:974-42-5
Molecular Formula:C₂₀H₂₁N₃O
Molecular Weight:319.406
Hs Code.:
DSSTox Substance ID:DTXSID501177885
Nikkaji Number:J3.286.035D
ChEMBL ID:CHEMBL4168081

Synonyms:SCHEMBL7706497;CHEMBL4168081;DTXSID501177885;AKOS005067464;1-Phenyl-8-benzyl-1,3,8-triazaspiro[4.5]deca-2-ene-4-one;1-Phenyl-8-(phenylmethyl)-1,3,8-triazaspiro[4.5]dec-2-en-4-one;974-42-5

Suppliers and Price of 1-Phenyl-8-benzyl-1,3,8-triazaspiro[4.5]deca-2-ene-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Phenyl-8-benzyl-1,3,8-triazaspiro[4.5]deca-2-ene-4-one

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:319.168462302
Heavy Atom Count:24
Complexity:469

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC12C(=O)N=CN2C3=CC=CC=C3)CC4=CC=CC=C4

Technology Process of 1-Phenyl-8-benzyl-1,3,8-triazaspiro[4.5]deca-2-ene-4-one

There total 6 articles about 1-Phenyl-8-benzyl-1,3,8-triazaspiro[4.5]deca-2-ene-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1096-03-3
1-benzyl-4-phenylaminopiperidine-4-carboxylic acid amide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 974-42-5
1-(phenylmethyl)-4,4-(2-phenyl-2,4-diaza-4-oxo-cyclopentane)piperidine

Guidance literature:: In methanol; at 55 ℃; for 16h;
DOI:10.1021/acs.jmedchem.8b00278

Reference yield:

: 968-86-5
1-benzyl-4-(phenylamino)piperidine-4-carbonitrile

: 974-42-5
1-(phenylmethyl)-4,4-(2-phenyl-2,4-diaza-4-oxo-cyclopentane)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 90percent H₂SO₄ / 20 h

2: AcOH / toluene / 20 h / Heating

With sulfuric acid; acetic acid; In toluene;
DOI:10.1021/jm950676i

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 974-42-5
1-(phenylmethyl)-4,4-(2-phenyl-2,4-diaza-4-oxo-cyclopentane)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: AcOH / H₂O / 48 h / Ambient temperature

2: 90percent H₂SO₄ / 20 h

3: AcOH / toluene / 20 h / Heating

With sulfuric acid; acetic acid; In water; toluene;
DOI:10.1021/jm950676i