N-(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide-d₉

Base Information

• Chemical Name: N-(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide-d₉
• CAS No.: 1423120-07-3
• Molecular Formula: C₂₃H₁₈ClF₃N₄O₂S₂
• Molecular Weight: 547.93

Synonyms:N-(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide-d₉

Chemical Property of N-(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide-d₉

Chemical Property:

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Technology Process of N-(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide-d₉

There total 8 articles about N-(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide-d₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide (1195768-20-7) + 2,2-dimethylpropanethioamide-d9 (1423120-03-9) → N-(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide-d9 (1423120-07-3)

Guidance literature:

N-(3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide; With N-Bromosuccinimide; In N,N-dimethyl acetamide; at 20 ℃; for 3h;

2,2-dimethylpropanethioamide-d₉; In N,N-dimethyl-formamide; at 65 ℃; for 12h;

Reference yield:

2,2-dimethylpropanoic acid-d9 (42983-07-3) → N-(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide-d9 (1423120-07-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

1.2: 20 °C

2.1: Lawessons reagent / tetrahydrofuran / Reflux

3.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 3 h / 20 °C

3.2: 12 h / 65 °C

With Lawessons reagent; N-Bromosuccinimide; oxalyl dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

2,2-dimethylpropanamide-d9 (6045-07-4) → N-(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide-d9 (1423120-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Lawessons reagent / tetrahydrofuran / Reflux

2.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 3 h / 20 °C

2.2: 12 h / 65 °C

With Lawessons reagent; N-Bromosuccinimide; In tetrahydrofuran; N,N-dimethyl acetamide;

upstream raw materials:

3,3-dimethyl-2-butanone-d₁₂

2,2-dimethylpropanoic acid-d₉

2,2-dimethylpropanamide-d₉

N-(3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

Downstream raw materials:

N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide-d₉

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