[3-amino-5-(4-{2-[bis(2-chloroethyl)amino]ethoxy}acridin-9-ylamino)phenyl]methanol

Base Information

• Chemical Name: [3-amino-5-(4-{2-[bis(2-chloroethyl)amino]ethoxy}acridin-9-ylamino)phenyl]methanol
• CAS No.: 898908-49-1
• Molecular Formula: C₂₆H₂₈Cl₂N₄O₂
• Molecular Weight: 499.44
• Mol file: 898908-49-1.mol

Synonyms:[3-amino-5-(4-{2-[bis(2-chloroethyl)amino]ethoxy}acridin-9-ylamino)phenyl]methanol

Chemical Property of [3-amino-5-(4-{2-[bis(2-chloroethyl)amino]ethoxy}acridin-9-ylamino)phenyl]methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-amino-5-(4-{2-[bis(2-chloroethyl)amino]ethoxy}acridin-9-ylamino)phenyl]methanol

There total 4 articles about [3-amino-5-(4-{2-[bis(2-chloroethyl)amino]ethoxy}acridin-9-ylamino)phenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{2-[bis(2-chloroethyl)-amino]ethoxy}-9-chloro acridine (898833-63-1) + 3,5-diaminobenzyl alcohol dihydrochloride (28150-15-4) → [3-amino-5-(4-{2-[bis(2-chloroethyl)amino]ethoxy}acridin-9-ylamino)phenyl]methanol (898908-49-1)

Guidance literature:

With 4-methyl-morpholine; In ethanol; at 0 - 20 ℃;

DOI:10.1021/jm060197r

Reference yield:

4-{2-[bis(2-chloroethyl)amino]ethoxy}-10H-acridin-9-one (898833-62-0) → [3-amino-5-(4-{2-[bis(2-chloroethyl)amino]ethoxy}acridin-9-ylamino)phenyl]methanol (898908-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂; DMF / 0.67 h / 80 °C

2: N-methylmorpholine / ethanol / 0 - 20 °C

With 4-methyl-morpholine; thionyl chloride; N,N-dimethyl-formamide; In ethanol;

DOI:10.1021/jm060197r

Reference yield:

4-hydroxy-9-oxoacridine (31231-39-7) → [3-amino-5-(4-{2-[bis(2-chloroethyl)amino]ethoxy}acridin-9-ylamino)phenyl]methanol (898908-49-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 27 percent / KF; K₂CO₃ / dimethylformamide / 20 h / 20 °C

2: SOCl₂; DMF / 0.67 h / 80 °C

3: N-methylmorpholine / ethanol / 0 - 20 °C

With 4-methyl-morpholine; potassium fluoride; thionyl chloride; potassium carbonate; N,N-dimethyl-formamide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm060197r

upstream raw materials:

4-{2-[bis(2-chloroethyl)-amino]ethoxy}-9-chloro acridine

3,5-diaminobenzyl alcohol dihydrochloride

4-{2-[bis(2-chloroethyl)amino]ethoxy}-10H-acridin-9-one

4-hydroxy-9-oxoacridine