C₂₁H₂₀N₂O

Base Information

• Chemical Name: C₂₁H₂₀N₂O
• CAS No.: 1613614-62-2
• Molecular Formula: C₂₁H₂₀N₂O
• Molecular Weight: 316.403
• Mol file: 1613614-62-2.mol

Synonyms:C₂₁H₂₀N₂O

Chemical Property of C₂₁H₂₀N₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₀N₂O

There total 5 articles about C₂₁H₂₀N₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C21H22N2O (1541196-42-2) → C21H20N2O (1613614-62-2)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; dipotassium hydrogenphosphate; [Ni(1,2-dimethoxyethane)₂I₂]; tetra-(n-butyl)ammonium iodide; In benzonitrile; at 150 ℃; for 24h;

DOI:10.1002/chem.201403356

Reference yield:

C13H18O2 → C21H20N2O (1613614-62-2)

Guidance literature:

Multi-step reaction with 4 steps

1: methanol; sodium hydroxide / 60 °C

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 17 h / 0 - 20 °C

3: triethylamine / dichloromethane / 20 °C

4: copper(l) chloride; Duroquinone; sodium benzoate / o-xylene / 160 °C / Schlenk technique; Sealed tube

With methanol; sodium benzoate; oxalyl dichloride; Duroquinone; triethylamine; copper(l) chloride; sodium hydroxide; In dichloromethane; o-xylene; N,N-dimethyl-formamide;

DOI:10.1002/anie.201311263

Reference yield:

2-methyl-2-phenyl-valeric acid (4355-44-6) → C21H20N2O (1613614-62-2)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 17 h / 0 - 20 °C

2: triethylamine / dichloromethane / 20 °C

3: copper(l) chloride; Duroquinone; sodium benzoate / o-xylene / 160 °C / Schlenk technique; Sealed tube

With sodium benzoate; oxalyl dichloride; Duroquinone; triethylamine; copper(l) chloride; In dichloromethane; o-xylene; N,N-dimethyl-formamide;

DOI:10.1002/anie.201311263

upstream raw materials:

2-phenylpropionic acid methyl ester

2-methyl-2-phenyl-valeric acid

2-methyl-2-phenyl-valeryl chloride

C₂₁H₂₂N₂O