4-cyanophenyl thiocyanate

Base Information

• Chemical Name: 4-cyanophenyl thiocyanate
• CAS No.: 122148-91-8
• Molecular Formula: C₈H₄N₂S
• Molecular Weight: 160.199
• Mol file: 122148-91-8.mol

Synonyms:4-cyanophenyl thiocyanate

Chemical Property of 4-cyanophenyl thiocyanate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-cyanophenyl thiocyanate

There total 8 articles about 4-cyanophenyl thiocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

sodium thiocyanide (540-72-7) + 4-cyanobenzenediazonium benzo[d][1,3,2]dithiazol-2-ide 1,1,3,3-tetraoxide → 4-cyanophenyl thiocyanate (122148-91-8)

Guidance literature:

With copper; In acetonitrile; at 20 - 25 ℃; for 0.0833333h;

Reference yield: 62.0%

trimethylsilyl isothiocyanate (2290-65-5) + 4-cyanophenylboronic acid (126747-14-6) → 4-cyanophenyl thiocyanate (122148-91-8)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; oxygen; potassium carbonate; sodium fluoride; copper(l) chloride; In acetonitrile; at 20 ℃; for 12h; Molecular sieve;

DOI:10.1039/c4ob02208d

Reference yield: 59.0%

p-cyanophenyl methyl sulfide (21382-98-9) + (3,5-bis(trifluoromethyl)phenyl)(cyano)-l3-iodanyl trifluoromethanesulfonate → 4-cyanophenyl thiocyanate (122148-91-8)

Guidance literature:

In acetonitrile; at 60 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c5cc00875a

upstream raw materials:

4-thiocyanatoaniline

potassium cyanide

sodium thiocyanide

trimethylsilyl isothiocyanate

Downstream raw materials:

4-[(difluoromethyl)thio]benzonitrile

4-[(trifluoromethyl)sulphanyl]benzenecarbonitrile

[2-(2-{7-[3-(4-Cyano-phenyl)-2-methyl-isothioureido]-4-methyl-2-oxo-2H-chromen-3-yl}-acetylamino)-ethyl]-carbamic acid tert-butyl ester

[2-(2-{7-[3-(4-Cyano-phenyl)-thioureido]-4-methyl-2-oxo-2H-chromen-3-yl}-acetylamino)-ethyl]-carbamic acid tert-butyl ester

Refernces

• 1、 Dai, Jianjun,Shen, Xiao,Wu, Cheng,Xu, Huajian,Xu, Jun. "Synthesis of (benzenesulfonyl)difluoromethyl thioethers from ((difluoromethyl)sulfonyl)benzene and organothiocyanates generatedin situ". supporting information. p. 7607 - 7610. Retrieved 2021/09/22.
• 2、 Exner, Benjamin,Bayarmagnai, Bilguun,Matheis, Christian,Goossen, Lukas J.. "Synthesis of perfluoroalkyl thioethers from aromatic thiocyanates by iron-catalysed decarboxylative perfluoroalkylation". supporting information. p. 89 - 93. Retrieved 2017/06/23.