isobutyl 6-formyl-2-methyl-4-(2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate

Base Information

• Chemical Name: isobutyl 6-formyl-2-methyl-4-(2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate
• CAS No.: 77581-34-1
• Molecular Formula: C₂₁H₂₂N₂O₅
• Molecular Weight: 382.416
• Mol file: 77581-34-1.mol

Synonyms:isobutyl 6-formyl-2-methyl-4-(2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate

Chemical Property of isobutyl 6-formyl-2-methyl-4-(2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isobutyl 6-formyl-2-methyl-4-(2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate

There total 5 articles about isobutyl 6-formyl-2-methyl-4-(2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.3%

isobutyl 6-dimethoxymethyl-2-methyl-4-(2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate (77581-31-8) → isobutyl 6-formyl-2-methyl-4-(2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate (77581-34-1)

Guidance literature:

With hydrogenchloride; In acetone; for 1h; Ambient temperature;

DOI:10.1248/cpb.39.3189

Reference yield:

isobutyl 6-dimethoxymethyl-2-methyl-4-(2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate (77581-31-8) → n-propyl 6-formyl-2-methyl-4-(2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate (77581-33-0) + isobutyl 6-formyl-2-methyl-4-(2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate (77581-34-1)

Guidance literature:

With hydrogenchloride;

Reference yield:

4,4-dimethoxy-3-oxo-butyric acid methyl ester (60705-25-1) → isobutyl 6-formyl-2-methyl-4-(2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate (77581-34-1)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / benzene / 3 h / Heating

2: 35.6 percent / 8.5 h / 95 - 120 °C

3: 33.3 percent / 6 N aq. HCl / acetone / 1 h / Ambient temperature

With piperidine; hydrogenchloride; In acetone; benzene;

DOI:10.1248/cpb.39.3189

upstream raw materials:

isobutyl 6-dimethoxymethyl-2-methyl-4-(2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate

4,4-dimethoxy-3-oxo-butyric acid methyl ester

methyl 2-(2-cyanobenzylidene)-4,4-dimethoxy acetoacetate

o-formylbenzonitrile

Downstream raw materials:

n-propyl 6-cyano-2-methyl-4-(2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate

Isobutyl 6-cyano-2-methyl-4 (2-cyanophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylate

4-(2-Cyano-phenyl)-2-hydroxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-isobutyl ester 3-methyl ester