3-(3-Ethoxy-4-methoxyphenyl)tetrahydro-4H-pyran-4-one

Base Information

Chemical Name:3-(3-Ethoxy-4-methoxyphenyl)tetrahydro-4H-pyran-4-one
CAS No.:907997-18-6
Molecular Formula:C₁₄H₁₈O₄
Molecular Weight:250.295
Hs Code.:
DSSTox Substance ID:DTXSID501214334
Nikkaji Number:J2.369.484K

Synonyms:3-(3-Ethoxy-4-methoxyphenyl)tetrahydro-4H-pyran-4-one;SCHEMBL1822961;DTXSID501214334;907997-18-6

Suppliers and Price of 3-(3-Ethoxy-4-methoxyphenyl)tetrahydro-4H-pyran-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(3-Ethoxy-4-methoxyphenyl)tetrahydro-4H-pyran-4-one

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:250.12050905
Heavy Atom Count:18
Complexity:279

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC1=C(C=CC(=C1)C2COCCC2=O)OC

Technology Process of 3-(3-Ethoxy-4-methoxyphenyl)tetrahydro-4H-pyran-4-one

There total 9 articles about 3-(3-Ethoxy-4-methoxyphenyl)tetrahydro-4H-pyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 881919-71-7
2-(3-ethoxy-4-methoxyphenyl)-1,4-pentadien-3-one

: 907997-18-6
3-(3-ethoxy-4-methoxyphenyl)tetrahydropyran-4-one

Guidance literature:: With potassium hydroxide; In dichloromethane; water; at 40 ℃; for 50h;
DOI:10.1002/ejoc.200600372

Reference yield:

: 881919-73-9
2-(3-ethoxy-4-methoxyphenyl)-1,4-pentadien-3-ol

: 907997-18-6
3-(3-ethoxy-4-methoxyphenyl)tetrahydropyran-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: MnO₂ / CH₂Cl₂ / 1 h / 23 °C

2: 25 percent / aq. KOH / CH₂Cl₂ / 72 h / 40 °C

With manganese(IV) oxide; potassium hydroxide; In dichloromethane;
DOI:10.1055/s-2006-941572

Reference yield:

: 881919-79-5
1-bromo-1-(3-ethoxy-4-methoxyphenyl)ethene

: 907997-18-6
3-(3-ethoxy-4-methoxyphenyl)tetrahydropyran-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; pentane / 1.5 h / -78 °C

1.2: 64 percent / tetrahydrofuran; pentane / 1.5 h / -78 °C

2.1: MnO₂ / CH₂Cl₂ / 1 h / 23 °C

3.1: 25 percent / aq. KOH / CH₂Cl₂ / 72 h / 40 °C

With manganese(IV) oxide; potassium hydroxide; n-butyllithium; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1055/s-2006-941572