tert-butyl 4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidine-1-carboxylate
• CAS No.: 1227068-92-9
• Molecular Formula: C₂₈H₂₉N₅O₄
• Molecular Weight: 499.569

Synonyms:tert-butyl 4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidine-1-carboxylate

There total 2 articles about tert-butyl 4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone (1227060-00-5) + tert-butyl 4-(3-chloropyrazin-2-yl)piperidine-1-carboxylate (1349184-43-5) → tert-butyl 4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidine-1-carboxylate (1227068-92-9)

Guidance literature:

With caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 0.666667h; Microwave irradiation;

DOI:10.1021/acsmedchemlett.6b00185

Reference yield:

tert-butyl 4-(3-fluoropyrazin-2-yl)piperidine-1-carboxylate (1104083-04-6) + (1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone (1227060-00-5) → tert-butyl 4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidine-1-carboxylate (1227068-92-9)

Guidance literature:

With caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

tert-butyl 4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidine-1-carboxylate (1227068-92-9) → (1H-benzo[d]imidazol-2-yl)(4-(3-(piperidin-4-yl)pyrazin-2-yloxy)phenyl)methanone (1227067-67-5)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 20 ℃; for 18h;

upstream raw materials:

tert-butyl 4-(3-fluoropyrazin-2-yl)piperidine-1-carboxylate

(1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone

tert-butyl 4-(3-chloropyrazin-2-yl)piperidine-1-carboxylate

Downstream raw materials:

(1H-benzo[d]imidazol-2-yl)(4-(3-(piperidin-4-yl)pyrazin-2-yloxy)phenyl)methanone

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