(2E,4S,6S,7S,9E,11E,13E)-1-[(t-butyldimethylsilyl)oxy]-6-hydroxy-3,7,9,13-tetramethyl-14-(2'-methyl-4'-oxazolyl)-4-[(triisopropylsilyl)oxy]-2,9,11,13-tetradecatetraen-8-one

Base Information

Chemical Name:(2E,4S,6S,7S,9E,11E,13E)-1-[(t-butyldimethylsilyl)oxy]-6-hydroxy-3,7,9,13-tetramethyl-14-(2'-methyl-4'-oxazolyl)-4-[(triisopropylsilyl)oxy]-2,9,11,13-tetradecatetraen-8-one
CAS No.:237735-30-7
Molecular Formula:C₃₇H₆₅NO₅Si₂
Molecular Weight:660.098
Hs Code.:

(2E,4S,6S,7S,9E,11E,13E)-1-[(t-butyldimethylsilyl)oxy]-6-hydroxy-3,7,9,13-tetramethyl-14-(2'-methyl-4'-oxazolyl)-4-[(triisopropylsilyl)oxy]-2,9,11,13-tetradecatetraen-8-one

Synonyms:(2E,4S,6S,7S,9E,11E,13E)-1-[(t-butyldimethylsilyl)oxy]-6-hydroxy-3,7,9,13-tetramethyl-14-(2'-methyl-4'-oxazolyl)-4-[(triisopropylsilyl)oxy]-2,9,11,13-tetradecatetraen-8-one

Suppliers and Price of (2E,4S,6S,7S,9E,11E,13E)-1-[(t-butyldimethylsilyl)oxy]-6-hydroxy-3,7,9,13-tetramethyl-14-(2'-methyl-4'-oxazolyl)-4-[(triisopropylsilyl)oxy]-2,9,11,13-tetradecatetraen-8-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2E,4S,6S,7S,9E,11E,13E)-1-[(t-butyldimethylsilyl)oxy]-6-hydroxy-3,7,9,13-tetramethyl-14-(2'-methyl-4'-oxazolyl)-4-[(triisopropylsilyl)oxy]-2,9,11,13-tetradecatetraen-8-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2E,4S,6S,7S,9E,11E,13E)-1-[(t-butyldimethylsilyl)oxy]-6-hydroxy-3,7,9,13-tetramethyl-14-(2'-methyl-4'-oxazolyl)-4-[(triisopropylsilyl)oxy]-2,9,11,13-tetradecatetraen-8-one

There total 1 articles about (2E,4S,6S,7S,9E,11E,13E)-1-[(t-butyldimethylsilyl)oxy]-6-hydroxy-3,7,9,13-tetramethyl-14-(2'-methyl-4'-oxazolyl)-4-[(triisopropylsilyl)oxy]-2,9,11,13-tetradecatetraen-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 237735-30-7
(2E,4S,6S,7S,9E,11E,13E)-1-[(t-butyldimethylsilyl)oxy]-6-hydroxy-3,7,9,13-tetramethyl-14-(2'-methyl-4'-oxazolyl)-4-[(triisopropylsilyl)oxy]-2,9,11,13-tetradecatetraen-8-one

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / 2,6-lutidine

2: 89 percent / DIBAL

3: 1) Et₃N, 2) imidazol, 3) DIBAL

4: 90 percent / Dess-Martin reagent

5: 100 percent

6: 96 percent / Dess-Martin reagent

7: 85 percent / Ba(OH)2*H₂O

8: 86 percent / H₂SiF₆ / propan-2-ol / -40 °C

With 1H-imidazole; 2,6-dimethylpyridine; barium dihydroxide; fluorosilicic acid; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; In isopropyl alcohol;
DOI:10.1016/S0040-4039(99)00731-5

Reference yield: 83.0%

: 555-16-8
4-nitrobenzaldehdye

: 237735-30-7
(2E,4S,6S,7S,9E,11E,13E)-1-[(t-butyldimethylsilyl)oxy]-6-hydroxy-3,7,9,13-tetramethyl-14-(2'-methyl-4'-oxazolyl)-4-[(triisopropylsilyl)oxy]-2,9,11,13-tetradecatetraen-8-one

: 544429-53-0
(2E,4S,6S,7S,8R,9E,11E,13E)-1-[(t-butyldimethylsilyl)oxy]-3,7,9,13-tetramethyl-14-(2'-methyl-4'-oxazolyl)-6-(p-nitrobenzoate)-4-[(triisopropylsilyl)oxy]-2,9,11,13-tetradecatetraen-8-ol

Guidance literature:: With samarium diiodide;
DOI:10.1016/S0040-4039(99)00731-5

Reference yield:

: 237735-30-7
(2E,4S,6S,7S,9E,11E,13E)-1-[(t-butyldimethylsilyl)oxy]-6-hydroxy-3,7,9,13-tetramethyl-14-(2'-methyl-4'-oxazolyl)-4-[(triisopropylsilyl)oxy]-2,9,11,13-tetradecatetraen-8-one

: 237735-31-8
(2E,4S,6S,7S,8R,9E,11E,13E)-3,7,9,13-tetramethyl-8-methoxy-14-(2'-methyl-4'-oxazolyl)-6-(p-nitrobenzoate)-4-[(triisopropylsilyl)oxy]-2,9,11,13-tetradecatetraen-1-al

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / SmI₂ / tetrahydrofuran / 3.5 h / -10 °C

2: 77 percent / Ag₂O; molecular sieves 3 Angstroem / benzene / 12 h / sonication

3: 94 percent / H₂SiF₆ / acetonitrile; 2-methyl-propan-2-ol; H₂O / 21 h / 0 °C

4: 82 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.67 h / 0 - 20 °C

With fluorosilicic acid; samarium diiodide; 3 A molecular sieve; Dess-Martin periodane; silver(l) oxide; In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/jo034011x