trans-4-{(2-fluoro-phenyl)-[(E/Z)-hydroxyimino]-methyl}-cyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:trans-4-{(2-fluoro-phenyl)-[(E/Z)-hydroxyimino]-methyl}-cyclohexanecarboxylic acid methyl ester
CAS No.:1429900-65-1
Molecular Formula:C₁₅H₁₈FNO₃
Molecular Weight:279.311
Hs Code.:

Synonyms:trans-4-{(2-fluoro-phenyl)-[(E/Z)-hydroxyimino]-methyl}-cyclohexanecarboxylic acid methyl ester

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Chemical Property of trans-4-{(2-fluoro-phenyl)-[(E/Z)-hydroxyimino]-methyl}-cyclohexanecarboxylic acid methyl ester

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Technology Process of trans-4-{(2-fluoro-phenyl)-[(E/Z)-hydroxyimino]-methyl}-cyclohexanecarboxylic acid methyl ester

There total 3 articles about trans-4-{(2-fluoro-phenyl)-[(E/Z)-hydroxyimino]-methyl}-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1005502-63-5
trans-4-(2-fluoro-benzoyl)-cyclohexanecarboxylic acid methyl ester

: 1429900-65-1
trans-4-{(2-fluoro-phenyl)-[(E/Z)-hydroxyimino]-methyl}-cyclohexanecarboxylic acid methyl ester

Guidance literature:: With hydroxylamine hydrochloride; sodium acetate; at 20 ℃;

Reference yield:

: 32529-80-9,36218-60-7
trans-1-chlorocarbonyl-4-(methoxycarbonyl)-cyclohexane

: 1429900-65-1
trans-4-{(2-fluoro-phenyl)-[(E/Z)-hydroxyimino]-methyl}-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 0 - 20 °C

1.2: 1 h / 20 °C

1.3: 20 °C

2.1: sodium acetate; hydroxylamine hydrochloride / 20 °C

With hydroxylamine hydrochloride; isopropylmagnesium chloride; sodium acetate; In tetrahydrofuran; 1.1: |Negishi Coupling / 1.2: |Negishi Coupling / 1.3: |Negishi Coupling;

Reference yield:

: 15177-67-0
trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid

: 1429900-65-1
trans-4-{(2-fluoro-phenyl)-[(E/Z)-hydroxyimino]-methyl}-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 24 h / 0 - 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 0 - 20 °C

2.2: 1 h / 20 °C

2.3: 20 °C

3.1: sodium acetate; hydroxylamine hydrochloride / 20 °C

With oxalyl dichloride; hydroxylamine hydrochloride; isopropylmagnesium chloride; sodium acetate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; 2.1: |Negishi Coupling / 2.2: |Negishi Coupling / 2.3: |Negishi Coupling;