1-azido-3-(7-bromo-heptyl)-benzene

Base Information

• Chemical Name: 1-azido-3-(7-bromo-heptyl)-benzene
• CAS No.: 213267-11-9
• Molecular Formula: C₁₃H₁₈BrN₃
• Molecular Weight: 296.21
• Mol file: 213267-11-9.mol

Synonyms:1-azido-3-(7-bromo-heptyl)-benzene

Chemical Property of 1-azido-3-(7-bromo-heptyl)-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-azido-3-(7-bromo-heptyl)-benzene

There total 4 articles about 1-azido-3-(7-bromo-heptyl)-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

7-(3-azido-phenyl)-heptan-1-ol (236754-30-6) → 1-azido-3-(7-bromo-heptyl)-benzene (213267-11-9)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1016/S0040-4020(99)00375-0

Reference yield:

ethyl 8-oxo-octanoate (1540-83-6) → 1-azido-3-(7-bromo-heptyl)-benzene (213267-11-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropylamide / hexane; tetrahydrofuran / 0.33 h / -20 °C

1.2: tetrahydrofuran; hexane / 2 h / -20 °C

1.3: 93 percent / hydrogen / 10 percent Pd on charcoal / methanol; benzene / 3 h / 20 °C

2.1: 92 percent / sodium azide / H₂O; acetic acid / 0.25 h / 0 °C

3.1: 96 percent / tetrabromomethane; triphenylphosphine / CH₂Cl₂ / 0.17 h / 20 °C

With sodium azide; carbon tetrabromide; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; water; acetic acid; 1.1: Elimination / 1.2: Addition / 1.3: Hydrogenation / 2.1: Diazotization / 3.1: Bromination;

DOI:10.1016/S0040-4020(99)00375-0

Reference yield:

8-hydroxyoctanoic acid ethyl ester (93892-06-9) → 1-azido-3-(7-bromo-heptyl)-benzene (213267-11-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 61 percent / pyridine sulfur trioxide; triethylamine / dimethylsulfoxide / 1 h / 20 °C

2.1: lithium diisopropylamide / hexane; tetrahydrofuran / 0.33 h / -20 °C

2.2: tetrahydrofuran; hexane / 2 h / -20 °C

2.3: 93 percent / hydrogen / 10 percent Pd on charcoal / methanol; benzene / 3 h / 20 °C

3.1: 92 percent / sodium azide / H₂O; acetic acid / 0.25 h / 0 °C

4.1: 96 percent / tetrabromomethane; triphenylphosphine / CH₂Cl₂ / 0.17 h / 20 °C

With sodium azide; carbon tetrabromide; sulfur trioxide pyridine complex; triethylamine; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; water; acetic acid; dimethyl sulfoxide; 1.1: Oxidation / 2.1: Elimination / 2.2: Addition / 2.3: Hydrogenation / 3.1: Diazotization / 4.1: Bromination;

DOI:10.1016/S0040-4020(99)00375-0

upstream raw materials:

7-(3-azido-phenyl)-heptan-1-ol

ethyl 8-oxo-octanoate

8-hydroxyoctanoic acid ethyl ester

7-(3-aminophenyl)-1-heptanol

Downstream raw materials:

S-[7-(3-azidophenyl)heptyl]glutathione