4-benzyl-3,4-dihydro-2-(3-{[2-(3,4-dimethoxyphenyl)ethyl]-N-(tert-butoxycarbonyl)amino}propyl)-2H-1,4-benzoxazine

Base Information

Chemical Name:4-benzyl-3,4-dihydro-2-(3-{[2-(3,4-dimethoxyphenyl)ethyl]-N-(tert-butoxycarbonyl)amino}propyl)-2H-1,4-benzoxazine
CAS No.:212578-64-8
Molecular Formula:C₃₃H₄₂N₂O₅
Molecular Weight:546.707
Hs Code.:

Synonyms:4-benzyl-3,4-dihydro-2-(3-{[2-(3,4-dimethoxyphenyl)ethyl]-N-(tert-butoxycarbonyl)amino}propyl)-2H-1,4-benzoxazine

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Chemical Property of 4-benzyl-3,4-dihydro-2-(3-{[2-(3,4-dimethoxyphenyl)ethyl]-N-(tert-butoxycarbonyl)amino}propyl)-2H-1,4-benzoxazine

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Technology Process of 4-benzyl-3,4-dihydro-2-(3-{[2-(3,4-dimethoxyphenyl)ethyl]-N-(tert-butoxycarbonyl)amino}propyl)-2H-1,4-benzoxazine

There total 6 articles about 4-benzyl-3,4-dihydro-2-(3-{[2-(3,4-dimethoxyphenyl)ethyl]-N-(tert-butoxycarbonyl)amino}propyl)-2H-1,4-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 212578-28-4
[3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-propyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine

: 212578-64-8
4-benzyl-3,4-dihydro-2-(3-{[2-(3,4-dimethoxyphenyl)ethyl]-N-(tert-butoxycarbonyl)amino}propyl)-2H-1,4-benzoxazine

Guidance literature:: In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/jm970795t

Reference yield:

: (E)-3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-acrylic acid ethyl ester

: 212578-64-8
4-benzyl-3,4-dihydro-2-(3-{[2-(3,4-dimethoxyphenyl)ethyl]-N-(tert-butoxycarbonyl)amino}propyl)-2H-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / H₂ / Raney Ni / ethanol; H₂O / 4 h / 20 °C / 2585.7 Torr

2: 98 percent / KOH / ethanol / Heating

3: 83 percent / EDCI / CH₂Cl₂ / 5 h / Ambient temperature

4: 81 percent / BH₃*Me₂S / tetrahydrofuran / 4 h / Heating

5: 98 percent / CH₂Cl₂ / 3 h / 0 °C

With potassium hydroxide; dimethylsulfide borane complex; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; nickel; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm970795t

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 212578-64-8
4-benzyl-3,4-dihydro-2-(3-{[2-(3,4-dimethoxyphenyl)ethyl]-N-(tert-butoxycarbonyl)amino}propyl)-2H-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / EDCI / CH₂Cl₂ / 5 h / Ambient temperature

2: 81 percent / BH₃*Me₂S / tetrahydrofuran / 4 h / Heating

3: 98 percent / CH₂Cl₂ / 3 h / 0 °C

With dimethylsulfide borane complex; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm970795t