{[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester

Base Information

Chemical Name:{[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester
CAS No.:1415796-61-0
Molecular Formula:C₁₆H₁₅FN₂O₄
Molecular Weight:318.305
Hs Code.:

Synonyms:{[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester

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Chemical Property of {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester

Chemical Property:

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Technology Process of {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester

There total 3 articles about {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1415796-59-6
[(3-hydroxy-5-trifluoromethanesulfonyloxypyridine-2-carbonyl)amino]acetic acid ethyl ester sodium salt

: 768-35-4
3-fluorophenylboronic acid

: 1415796-61-0
{[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester

Guidance literature:: [(3-hydroxy-5-trifluoromethanesulfonyloxypyridine-2-carbonyl)amino]acetic acid ethyl ester sodium salt; 3-fluorophenylboronic acid; With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 75 - 85 ℃; Inert atmosphere;

With hydrogenchloride; In water; ethyl acetate; at 18 - 25 ℃; for 0.5h;

Reference yield:

: 1007381-66-9
[(3,5-dihydroxypyridine-2-carbonyl)amino]acetic acid ethyl ester

: 1415796-61-0
{[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / ethanol / 0 - 40 °C / Inert atmosphere; Industry scale

2.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 75 - 85 °C / Inert atmosphere

2.2: 0.5 h / 18 - 25 °C

With potassium phosphate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; ethanol; water;

Reference yield:

: 1415796-58-5
[(3,5-bisbenzyloxypyridine-2-carbonyl)amino]acetic acid ethyl ester

: 1415796-61-0
{[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 18 - 25 °C / Inert atmosphere; Industry scale

2.1: triethylamine / ethanol / 0 - 40 °C / Inert atmosphere; Industry scale

3.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 75 - 85 °C / Inert atmosphere

3.2: 0.5 h / 18 - 25 °C

With potassium phosphate; hydrogen; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; water;