N,5-dimethyl-N-<4'-<4''-(methylamino)-3''-nitrobenzyl>-2'-nitrophenyl>pyridine-2-carboxamide

Base Information

• Chemical Name: N,5-dimethyl-N-<4'-<4''-(methylamino)-3''-nitrobenzyl>-2'-nitrophenyl>pyridine-2-carboxamide
• CAS No.: 156818-63-2
• Molecular Formula: C₂₂H₂₁N₅O₅
• Molecular Weight: 435.439
• Mol file: 156818-63-2.mol

Synonyms:N,5-dimethyl-N-<4'-<4''-(methylamino)-3''-nitrobenzyl>-2'-nitrophenyl>pyridine-2-carboxamide

Chemical Property of N,5-dimethyl-N-<4'-<4''-(methylamino)-3''-nitrobenzyl>-2'-nitrophenyl>pyridine-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,5-dimethyl-N-<4'-<4''-(methylamino)-3''-nitrobenzyl>-2'-nitrophenyl>pyridine-2-carboxamide

There total 6 articles about N,5-dimethyl-N-<4'-<4''-(methylamino)-3''-nitrobenzyl>-2'-nitrophenyl>pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4,4’-methylene-2,2’-dinitro-bis(N-methyl-aniniline) (100974-85-4) + 5-methylpyridine-2-carboxylic acid chloride (128073-07-4) → N,5-dimethyl-N-<4'-<4''-(methylamino)-3''-nitrobenzyl>-2'-nitrophenyl>pyridine-2-carboxamide (156818-63-2)

Guidance literature:

With triethylamine; In chloroform; for 15h; Ambient temperature;

DOI:10.1002/hlca.19940770406

Reference yield:

2-carboxy-5-methylpyridine (4434-13-3) → N,5-dimethyl-N-<4'-<4''-(methylamino)-3''-nitrobenzyl>-2'-nitrophenyl>pyridine-2-carboxamide (156818-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / dimethylformamide / 1.5 h / Heating

2: 50 percent / Et₃N / CHCl₃ / 15 h / Ambient temperature

With thionyl chloride; triethylamine; In chloroform; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19940770406

Reference yield:

2-Chloronitrobenzene (88-73-3) → N,5-dimethyl-N-<4'-<4''-(methylamino)-3''-nitrobenzyl>-2'-nitrophenyl>pyridine-2-carboxamide (156818-63-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water / 24 h / 130 °C / Autoclave

2.1: hydrogenchloride / water / 1 h / 40 °C / Heating

2.2: 1 h / 60 °C / Heating

2.3: 1 h / 120 °C / Heating

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / pH 7 - 8 / Reflux; Inert atmosphere

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; water;

DOI:10.1039/c4dt02336f

upstream raw materials:

4,4’-methylene-2,2’-dinitro-bis(N-methyl-aniniline)

5-methylpyridine-2-carboxylic acid chloride

2-carboxy-5-methylpyridine

2-nitro-N-methylaniline

Downstream raw materials:

N,N'-5,5'-tetramethyl,N,N'-(3-nitrophen-4,1-ylene)methylene(2-nitrophen-4,1-ylene)>>bis

Pyridine-2,6-dicarboxylic acid 2-diethylamide 6-[methyl-(4-{4-[methyl-(5-methyl-pyridine-2-carbonyl)-amino]-3-nitro-benzyl}-2-nitro-phenyl)-amide]