(1,2-trans)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylic acid

Base Information

Chemical Name:(1,2-trans)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylic acid
CAS No.:1445590-33-9
Molecular Formula:C₁₄H₁₃BrN₂O₂
Molecular Weight:321.173
Hs Code.:

Synonyms:(1,2-trans)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylic acid

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Chemical Property of (1,2-trans)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylic acid

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Technology Process of (1,2-trans)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylic acid

There total 2 articles about (1,2-trans)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1445590-32-8
(1,2-trans)-1-(2-(4-bromophenyl)-2-oxoethyl) 2-methyl cyclobutane-1,2-dicarboxylate

: 1445590-33-9
(1,2-trans)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylic acid

Guidance literature:: With ammonium acetate; In 5,5-dimethyl-1,3-cyclohexadiene; at 120 ℃; for 6h; Sealed tube;

Reference yield:

: 99-73-0,132309-76-3
para-bromophenacyl bromide

: 1445590-33-9
(1,2-trans)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 0 - 20 °C

2: ammonium acetate / 5,5-dimethyl-1,3-cyclohexadiene / 6 h / 120 °C / Sealed tube

With ammonium acetate; N-ethyl-N,N-diisopropylamine; In 5,5-dimethyl-1,3-cyclohexadiene; acetonitrile;

Reference yield: 76.0%

: 953780-78-4,192661-47-5
(3R)-3-methylmorpholine hydrochloride

: 1445590-33-9
(1,2-trans)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylic acid

: 1445590-34-0
((1,2-trans)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutyl)((R)-3-methylmorpholino)methanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; Inert atmosphere;