1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-3-azetidinecarboxylic acid

Base Information

Chemical Name:1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-3-azetidinecarboxylic acid
CAS No.:1334606-83-5
Molecular Formula:C₂₇H₂₈F₃N₃O₃
Molecular Weight:499.533
Hs Code.:

Synonyms:1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-3-azetidinecarboxylic acid

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Chemical Property of 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-3-azetidinecarboxylic acid

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Technology Process of 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-3-azetidinecarboxylic acid

There total 7 articles about 1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-3-azetidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334607-97-4
2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}benzaldehyde

: 36476-78-5
3-azetidinecarboxylic acid

: 1334606-83-5
1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-3-azetidinecarboxylic acid

Guidance literature:: 2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}benzaldehyde; 3-azetidinecarboxylic acid; With acetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

: 393-37-3
5-bromo-2-fluorobenzotrifluoride

: 1334606-83-5
1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-3-azetidinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 50 °C / Inert atmosphere

1.2: 50 °C

2.1: n-butyllithium / tetrahydrofuran / -78 - -60 °C

2.2: -60 - 20 °C

2.3: 20 °C

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

4.1: acetic acid / dichloromethane / 1 h / 20 °C

4.2: 20 °C

With potassium phosphate; n-butyllithium; potassium tert-butylate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 2357-47-3
4-Fluoro-3-trifluoromethylaniline

: 1334606-83-5
1-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-3-azetidinecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 20 °C / Cooling with ice; Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 50 °C / Inert atmosphere

2.2: 50 °C

3.1: n-butyllithium / tetrahydrofuran / -78 - -60 °C

3.2: -60 - 20 °C

3.3: 20 °C

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

5.1: acetic acid / dichloromethane / 1 h / 20 °C

5.2: 20 °C

With potassium phosphate; n-butyllithium; tert.-butylnitrite; potassium tert-butylate; acetic acid; copper(ll) bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;