N-[N'-(1(S)-carboxy-3-phenylpropyl)-L-alanyl]-(4R)-4-[3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy]-L-proline S,S-dioxide

Base Information

Chemical Name:N-[N'-(1(S)-carboxy-3-phenylpropyl)-L-alanyl]-(4R)-4-[3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy]-L-proline S,S-dioxide
CAS No.:103580-46-7
Molecular Formula:C₂₇H₃₄ClN₅O₁₀S₂
Molecular Weight:688.179
Hs Code.:

Synonyms:N-[N'-(1(S)-carboxy-3-phenylpropyl)-L-alanyl]-(4R)-4-[3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy]-L-proline S,S-dioxide

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Chemical Property of N-[N'-(1(S)-carboxy-3-phenylpropyl)-L-alanyl]-(4R)-4-[3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy]-L-proline S,S-dioxide

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Technology Process of N-[N'-(1(S)-carboxy-3-phenylpropyl)-L-alanyl]-(4R)-4-[3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy]-L-proline S,S-dioxide

There total 4 articles about N-[N'-(1(S)-carboxy-3-phenylpropyl)-L-alanyl]-(4R)-4-[3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy]-L-proline S,S-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126257-65-6
(4R)-N-(carbobenzyloxy)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester

: 103580-46-7
N-[N'-(1(S)-carboxy-3-phenylpropyl)-L-alanyl]-(4R)-4-[3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy]-L-proline S,S-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: 2.49 g / H₂, Et₃N / 10percent Pd/C / 3 h / 2068.6 Torr

2: 1.) 1,1-carbonyldiimidazole / 1.) CH₂Cl₂, from 0 to 5 deg C, 30 min, 2.) 25 deg C, overnight

3: camphorosulfonic acid / ethanol / 48 h / 25 °C

4: aq. NaOH / ethanol

With sodium hydroxide; camphor-10-sulfonic acid; hydrogen; triethylamine; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00168a013

Reference yield:

: 126257-68-9
N--L-alanyl>-(4R)-4-<3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy>-L-proline ethyl ester S,S-dioxide

: 103580-46-7
N-[N'-(1(S)-carboxy-3-phenylpropyl)-L-alanyl]-(4R)-4-[3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy]-L-proline S,S-dioxide

Guidance literature:: With sodium hydroxide; In ethanol;
DOI:10.1021/jm00168a013

Reference yield:

: 126257-66-7
(2S,4R)-4-(2-[1,3]Dioxolan-2-yl-ethoxy)-pyrrolidine-2-carboxylic acid ethyl ester

: 103580-46-7
N-[N'-(1(S)-carboxy-3-phenylpropyl)-L-alanyl]-(4R)-4-[3-(6-chloro-7-sulfamyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-yl)propoxy]-L-proline S,S-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1,1-carbonyldiimidazole / 1.) CH₂Cl₂, from 0 to 5 deg C, 30 min, 2.) 25 deg C, overnight

2: camphorosulfonic acid / ethanol / 48 h / 25 °C

3: aq. NaOH / ethanol

With sodium hydroxide; camphor-10-sulfonic acid; 1,1'-carbonyldiimidazole; In ethanol;
DOI:10.1021/jm00168a013