C₂₂H₁₄ClF₃N₂O

Base Information

Chemical Name:C₂₂H₁₄ClF₃N₂O
CAS No.:1335242-71-1
Molecular Formula:C₂₂H₁₄ClF₃N₂O
Molecular Weight:414.814
Hs Code.:

C<sub>22</sub>H<sub>14</sub>ClF<sub>3</sub>N<sub>2</sub>O

Synonyms:C₂₂H₁₄ClF₃N₂O

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Chemical Property of C₂₂H₁₄ClF₃N₂O

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Technology Process of C₂₂H₁₄ClF₃N₂O

There total 4 articles about C₂₂H₁₄ClF₃N₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1749-03-7
N-(4-chlorobenzylidene)-4-methoxyaniline

: 1335243-01-0
C₁₅H₁₁F₃N₂O

: 1335242-71-1
C₂₂H₁₄ClF₃N₂O

Guidance literature:: C₁₅H₁₁F₃N₂O; With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; In tetrahydrofuran; at 20 ℃; for 0.166667h; Molecular sieve; Inert atmosphere;

N-(4-chlorobenzylidene)-4-methoxyaniline; In tetrahydrofuran; at 20 ℃; for 70h; optical yield given as %ee; enantioselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1021/ol202361t

Reference yield:

: 461-82-5
4-(trifluoromethoxy)aniline

: 1335242-71-1
C₂₂H₁₄ClF₃N₂O

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine; acetic acid / 4.5 h / 20 °C / Molecular sieve

2.1: n-butyllithium / diethyl ether; hexane / -78 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

4.1: (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate / tetrahydrofuran / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere

4.2: 70 h / 20 °C / Molecular sieve; Inert atmosphere

With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; bromine; sodium carbonate; acetic acid; In tetrahydrofuran; diethyl ether; hexane; water; N,N-dimethyl-formamide; 4.1: Pictet-Spengler cyclisation / 4.2: Pictet-Spengler cyclisation;
DOI:10.1021/ol202361t

Reference yield:

: 88149-49-9
2,6-dibromo-4-(trifluoromethoxy)aniline

: 1335242-71-1
C₂₂H₁₄ClF₃N₂O

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / -78 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

3.1: (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate / tetrahydrofuran / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere

3.2: 70 h / 20 °C / Molecular sieve; Inert atmosphere

With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; sodium carbonate; In tetrahydrofuran; diethyl ether; hexane; water; N,N-dimethyl-formamide; 3.1: Pictet-Spengler cyclisation / 3.2: Pictet-Spengler cyclisation;
DOI:10.1021/ol202361t