(1R,4aS,4bR,6aR,8S,10aR,10bS,12aS)-1-[(Dimethyl-phenyl-silanyl)-methyl]-8-hydroxy-4b,7,7,10a,12a-pentamethyl-hexadecahydro-chrysen-2-one

Base Information

Chemical Name:(1R,4aS,4bR,6aR,8S,10aR,10bS,12aS)-1-[(Dimethyl-phenyl-silanyl)-methyl]-8-hydroxy-4b,7,7,10a,12a-pentamethyl-hexadecahydro-chrysen-2-one
CAS No.:196938-00-8
Molecular Formula:C₃₂H₅₀O₂Si
Molecular Weight:494.833
Hs Code.:

Synonyms:(1R,4aS,4bR,6aR,8S,10aR,10bS,12aS)-1-[(Dimethyl-phenyl-silanyl)-methyl]-8-hydroxy-4b,7,7,10a,12a-pentamethyl-hexadecahydro-chrysen-2-one

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Chemical Property of (1R,4aS,4bR,6aR,8S,10aR,10bS,12aS)-1-[(Dimethyl-phenyl-silanyl)-methyl]-8-hydroxy-4b,7,7,10a,12a-pentamethyl-hexadecahydro-chrysen-2-one

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Technology Process of (1R,4aS,4bR,6aR,8S,10aR,10bS,12aS)-1-[(Dimethyl-phenyl-silanyl)-methyl]-8-hydroxy-4b,7,7,10a,12a-pentamethyl-hexadecahydro-chrysen-2-one

There total 1 articles about (1R,4aS,4bR,6aR,8S,10aR,10bS,12aS)-1-[(Dimethyl-phenyl-silanyl)-methyl]-8-hydroxy-4b,7,7,10a,12a-pentamethyl-hexadecahydro-chrysen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 196937-99-2
(1R,4aS,4bR,6aR,8S,10aR,10bS,12aS)-8-(tert-Butyl-dimethyl-silanyloxy)-1-[(dimethyl-phenyl-silanyl)-methyl]-4b,7,7,10a,12a-pentamethyl-hexadecahydro-chrysen-2-one

: 196938-00-8
(1R,4aS,4bR,6aR,8S,10aR,10bS,12aS)-1-[(Dimethyl-phenyl-silanyl)-methyl]-8-hydroxy-4b,7,7,10a,12a-pentamethyl-hexadecahydro-chrysen-2-one

Guidance literature:: With potassium hydroxide; hydrogen fluoride; Yield given. Multistep reaction; 1) CH₃CN; 2) MeOH, reflux, 3 h;
DOI:10.1021/ja972690l

Reference yield:

: 196938-00-8
(1R,4aS,4bR,6aR,8S,10aR,10bS,12aS)-1-[(Dimethyl-phenyl-silanyl)-methyl]-8-hydroxy-4b,7,7,10a,12a-pentamethyl-hexadecahydro-chrysen-2-one

: 196938-02-0
Trifluoro-methanesulfonic acid (1R,4aS,4bR,6aS,10aS,10bR,12aS)-1-[(dimethyl-phenyl-silanyl)-methyl]-4b,7,7,10a,12a-pentamethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydro-chrysen-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) C₆F₅OCSCl, DMAP, 2.) Bu₃SnH, AIBN / 1) CH₂Cl₂, 0-23 deg C, 10 h; 2) benzene, reflux, 3 h

2: 90 percent / KHMDS / tetrahydrofuran / 0.33 h / -78 °C

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; potassium hexamethylsilazane; pentafluorophenoxythiocarbonyl chloride; In tetrahydrofuran;
DOI:10.1021/ja972690l

Reference yield:

: 196938-00-8
(1R,4aS,4bR,6aR,8S,10aR,10bS,12aS)-1-[(Dimethyl-phenyl-silanyl)-methyl]-8-hydroxy-4b,7,7,10a,12a-pentamethyl-hexadecahydro-chrysen-2-one

: 196938-01-9
(1R,4aS,4bR,6aS,10aS,10bR,12aS)-1-[(Dimethyl-phenyl-silanyl)-methyl]-4b,7,7,10a,12a-pentamethyl-hexadecahydro-chrysen-2-one

Guidance literature:: With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; pentafluorophenoxythiocarbonyl chloride; Yield given. Multistep reaction; 1) CH₂Cl₂, 0-23 deg C, 10 h; 2) benzene, reflux, 3 h;
DOI:10.1021/ja972690l