carbamic acid, [(2E)-3-[4-(1H-pyrazol-1-yl)phenyl]-2-propenyl]-, (3aS,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-[[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]4-ethyltetradecahydro-8-hydroxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-2H-oxacyclotetradecino[4,3-d]oxazol-11-yl ester

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Chemical Name:carbamic acid, [(2E)-3-[4-(1H-pyrazol-1-yl)phenyl]-2-propenyl]-, (3aS,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-[[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]4-ethyltetradecahydro-8-hydroxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-2H-oxacyclotetradecino[4,3-d]oxazol-11-yl ester
CAS No.:631901-94-5
Molecular Formula:C₄₅H₆₅N₅O₁₂
Molecular Weight:868.037
Hs Code.:

carbamic acid, [(2E)-3-[4-(1H-pyrazol-1-yl)phenyl]-2-propenyl]-, (3aS,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-[[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]4-ethyltetradecahydro-8-hydroxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-2H-oxacyclotetradecino[4,3-d]oxazol-11-yl ester

Synonyms:carbamic acid, [(2E)-3-[4-(1H-pyrazol-1-yl)phenyl]-2-propenyl]-, (3aS,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-[[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]4-ethyltetradecahydro-8-hydroxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-2H-oxacyclotetradecino[4,3-d]oxazol-11-yl ester

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Chemical Property of carbamic acid, [(2E)-3-[4-(1H-pyrazol-1-yl)phenyl]-2-propenyl]-, (3aS,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-[[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]4-ethyltetradecahydro-8-hydroxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-2H-oxacyclotetradecino[4,3-d]oxazol-11-yl ester

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Technology Process of carbamic acid, [(2E)-3-[4-(1H-pyrazol-1-yl)phenyl]-2-propenyl]-, (3aS,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-[[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]4-ethyltetradecahydro-8-hydroxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-2H-oxacyclotetradecino[4,3-d]oxazol-11-yl ester

There total 7 articles about carbamic acid, [(2E)-3-[4-(1H-pyrazol-1-yl)phenyl]-2-propenyl]-, (3aS,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-[[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]4-ethyltetradecahydro-8-hydroxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-2H-oxacyclotetradecino[4,3-d]oxazol-11-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 545424-10-0
(2E)-3-[4-(1H-Pyrazol-1-yl)phenyl]-2-propenal

: 433919-41-6
2H-oxacyclotetradecino[4,3-d]oxazole-2,6,14(1H,7H)-trione, 10-[[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-11-[(aminocarbonyl)oxy]-4-ethyldecahydro-8-hydroxy-3a,7,9,11,13,15-hexamethyl-, (3aS,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-

: 631901-94-5
carbamic acid, [(2E)-3-[4-(1H-pyrazol-1-yl)phenyl]-2-propenyl]-, (3aS,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-[[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]4-ethyltetradecahydro-8-hydroxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-2H-oxacyclotetradecino[4,3-d]oxazol-11-yl ester

Guidance literature:: (2E)-3-[4-(1H-Pyrazol-1-yl)phenyl]-2-propenal; 2H-oxacyclotetradecino[4,3-d]oxazole-2,6,14(1H,7H)-trione, 10-[[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-11-[(aminocarbonyl)oxy]-4-ethyldecahydro-8-hydroxy-3a,7,9,11,13,15-hexamethyl-, (3aS,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-; With triethylsilane; trifluoroacetic acid; In acetonitrile; at 65 ℃; for 18h;

With sodium hydrogencarbonate; In water; acetonitrile;

Reference yield:

: 545420-78-8
C₄₁H₆₉N₃O₁₅

: 631901-94-5
carbamic acid, [(2E)-3-[4-(1H-pyrazol-1-yl)phenyl]-2-propenyl]-, (3aS,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-[[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]4-ethyltetradecahydro-8-hydroxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-2H-oxacyclotetradecino[4,3-d]oxazol-11-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: t-BuOK / tetrahydrofuran / 0 °C

2: Et₃N / CH₂Cl₂

3: aq. HCl / ethanol / 20 °C

4: CF₃CO₂H; Et₃SiH / acetonitrile / 65 °C

With hydrogenchloride; triethylsilane; potassium tert-butylate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2005.10.074

Reference yield:

: 114-07-8
erythromycin

: 631901-94-5
carbamic acid, [(2E)-3-[4-(1H-pyrazol-1-yl)phenyl]-2-propenyl]-, (3aS,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-[[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]4-ethyltetradecahydro-8-hydroxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-2H-oxacyclotetradecino[4,3-d]oxazol-11-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N; 4-dimethylaminopyridine / CH₂Cl₂

2: NaN(TMS)2 / tetrahydrofuran / 0 °C

3: CH₂Cl₂ / 0 °C

4: Et₃N; H₂O / methanol / Heating

5: t-BuOK / tetrahydrofuran / 0 °C

6: Et₃N / CH₂Cl₂

7: aq. HCl / ethanol / 20 °C

8: CF₃CO₂H; Et₃SiH / acetonitrile / 65 °C

With hydrogenchloride; triethylsilane; dmap; potassium tert-butylate; water; sodium hexamethyldisilazane; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2005.10.074