tert-butyl 3,7-dimethyl-1-phenethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dihydro-1,4-epiminonaphthalene-9-carboxylate

Base Information

Chemical Name:tert-butyl 3,7-dimethyl-1-phenethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dihydro-1,4-epiminonaphthalene-9-carboxylate
CAS No.:1245635-02-2
Molecular Formula:C₃₁H₄₀BNO₄
Molecular Weight:501.474
Hs Code.:

Synonyms:tert-butyl 3,7-dimethyl-1-phenethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dihydro-1,4-epiminonaphthalene-9-carboxylate

Suppliers and Price of tert-butyl 3,7-dimethyl-1-phenethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dihydro-1,4-epiminonaphthalene-9-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 3,7-dimethyl-1-phenethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dihydro-1,4-epiminonaphthalene-9-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 3,7-dimethyl-1-phenethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dihydro-1,4-epiminonaphthalene-9-carboxylate

There total 8 articles about tert-butyl 3,7-dimethyl-1-phenethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dihydro-1,4-epiminonaphthalene-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373264-22-2
4-methyl-2-phenethyl-1-tosyl-1H-pyrrole

: 1245635-20-4
2-Iodo-4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl trifluoromethanesulfonate

: 1245635-02-2
tert-butyl 3,7-dimethyl-1-phenethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dihydro-1,4-epiminonaphthalene-9-carboxylate

: C₁₀H₄(CH₃)(CH₃)(C₂H₄C₆H₅)N(C(O)OC(CH₃)3)B(OC(CH₃)2)2

Guidance literature:: With TurboGrignard; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.583333h; Overall yield = 82 %; Overall yield = 49 mg; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2013.03.016

Reference yield:

: 1245635-17-9
[3-iodo-2-(methoxymethoxy)-5-methylphenyl]boronic acid

: 1245635-02-2
tert-butyl 3,7-dimethyl-1-phenethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dihydro-1,4-epiminonaphthalene-9-carboxylate

: C₁₀H₄(CH₃)(CH₃)(C₂H₄C₆H₅)N(C(O)OC(CH₃)3)B(OC(CH₃)2)2

Guidance literature:: Multi-step reaction with 4 steps

1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 0 - 20 °C

2: dichloromethane / 20 °C

3: pyridine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

4: TurboGrignard / tetrahydrofuran; diethyl ether / 0.58 h / -78 °C / Inert atmosphere

With pyridine; TurboGrignard; chloro-trimethyl-silane; sodium iodide; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; 4: |Diels-Alder Cycloaddition;
DOI:10.1016/j.tet.2013.03.016

Reference yield:

: 1245635-18-0
(2-hydroxy-3-iodo-5-methylphenyl)boronic acid

: 1245635-02-2
tert-butyl 3,7-dimethyl-1-phenethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dihydro-1,4-epiminonaphthalene-9-carboxylate

: C₁₀H₄(CH₃)(CH₃)(C₂H₄C₆H₅)N(C(O)OC(CH₃)3)B(OC(CH₃)2)2

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 20 °C

2: pyridine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

3: TurboGrignard / tetrahydrofuran; diethyl ether / 0.58 h / -78 °C / Inert atmosphere

With pyridine; TurboGrignard; In tetrahydrofuran; diethyl ether; dichloromethane; 3: |Diels-Alder Cycloaddition;
DOI:10.1016/j.tet.2013.03.016