3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-N-(1-ethyl-1H-pyrazol-3-yl)-5-hydroxybenzamide

Base Information

Chemical Name:3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-N-(1-ethyl-1H-pyrazol-3-yl)-5-hydroxybenzamide
CAS No.:871656-76-7
Molecular Formula:C₂₁H₃₃N₃O₄Si
Molecular Weight:419.596
Hs Code.:

Synonyms:3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-N-(1-ethyl-1H-pyrazol-3-yl)-5-hydroxybenzamide

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Chemical Property of 3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-N-(1-ethyl-1H-pyrazol-3-yl)-5-hydroxybenzamide

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Technology Process of 3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-N-(1-ethyl-1H-pyrazol-3-yl)-5-hydroxybenzamide

There total 7 articles about 3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-N-(1-ethyl-1H-pyrazol-3-yl)-5-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 871656-77-8
3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-N-(1-ethyl-1H-pyrazol-3-yl)-5-[(phenylmethyl)oxy]benzamide

: 871656-76-7
3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-N-(1-ethyl-1H-pyrazol-3-yl)-5-hydroxybenzamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 871656-59-6
methyl 3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-5-[(phenylmethyl)oxy]benzoate

: 871656-76-7
3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-N-(1-ethyl-1H-pyrazol-3-yl)-5-hydroxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide; water / tetrahydrofuran / 22 h / 20 - 45 °C

2: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 3 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 16 h / 20 °C

With lithium hydroxide; water; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide);

Reference yield:

: 871656-63-2
3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-5-[(phenylmethyl)oxy]benzoic acid

: 871656-76-7
3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-N-(1-ethyl-1H-pyrazol-3-yl)-5-hydroxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 3 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 16 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide);