N-((2S,3S)-3-trans-ethoxycarbonyloxiran-2-carbonyl)-D-phenylalanine benzyl amide

Base Information

Chemical Name:N-((2S,3S)-3-trans-ethoxycarbonyloxiran-2-carbonyl)-D-phenylalanine benzyl amide
CAS No.:159170-02-2
Molecular Formula:C₂₂H₂₄N₂O₅
Molecular Weight:396.443
Hs Code.:

Synonyms:N-((2S,3S)-3-trans-ethoxycarbonyloxiran-2-carbonyl)-D-phenylalanine benzyl amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2S,3S)-3-trans-ethoxycarbonyloxiran-2-carbonyl)-D-phenylalanine benzyl amide

Chemical Property:

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Technology Process of N-((2S,3S)-3-trans-ethoxycarbonyloxiran-2-carbonyl)-D-phenylalanine benzyl amide

There total 2 articles about N-((2S,3S)-3-trans-ethoxycarbonyloxiran-2-carbonyl)-D-phenylalanine benzyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3291-46-1,3291-47-2,61937-48-2,66647-17-4,74243-85-9,73890-18-3
(2S,3S)-diethyl oxirane-2,3-dicarboxylate

: 159170-02-2
N-((2S,3S)-3-trans-ethoxycarbonyloxiran-2-carbonyl)-D-phenylalanine benzyl amide

Guidance literature:: Multi-step reaction with 2 steps

1: 57.7 percent / 0.1M aq. KH₂PO₄, 1M aq. NaOH / 20 °C / pig liver esterase

2: 1.) DCC, 2.) HOBt / 1.) THF, 0.5 h, 2.) THF, a) -5 deg C, 1 h, b) 25 deg C, 2 d

With sodium hydroxide; potassium dihydrogenphosphate; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
DOI:10.1006/bioo.1994.1017

Reference yield:

: 63734-73-6,66647-16-3,68521-71-1,89886-73-7,93061-20-2,149884-11-7
ethyl (2S,3S)-2,3-epoxysuccinate

: 72244-52-1
(R)-N-benzyl 2-amino-3-phenylpropionamide

: 159170-02-2
N-((2S,3S)-3-trans-ethoxycarbonyloxiran-2-carbonyl)-D-phenylalanine benzyl amide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) THF, 0.5 h, 2.) THF, a) -5 deg C, 1 h, b) 25 deg C, 2 d;
DOI:10.1006/bioo.1994.1017