(2R,3R,4R,5R,6R)-5-[1-(4,5-Dimethoxy-2-nitro-phenyl)-2,2,2-trifluoro-ethoxy]-6-hydroxymethyl-2-p-tolyloxy-tetrahydro-pyran-3,4-diol

Base Information

Chemical Name:(2R,3R,4R,5R,6R)-5-[1-(4,5-Dimethoxy-2-nitro-phenyl)-2,2,2-trifluoro-ethoxy]-6-hydroxymethyl-2-p-tolyloxy-tetrahydro-pyran-3,4-diol
CAS No.:700362-47-6
Molecular Formula:C₂₃H₂₆F₃NO₁₀
Molecular Weight:533.455
Hs Code.:

Synonyms:(2R,3R,4R,5R,6R)-5-[1-(4,5-Dimethoxy-2-nitro-phenyl)-2,2,2-trifluoro-ethoxy]-6-hydroxymethyl-2-p-tolyloxy-tetrahydro-pyran-3,4-diol

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Chemical Property of (2R,3R,4R,5R,6R)-5-[1-(4,5-Dimethoxy-2-nitro-phenyl)-2,2,2-trifluoro-ethoxy]-6-hydroxymethyl-2-p-tolyloxy-tetrahydro-pyran-3,4-diol

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Technology Process of (2R,3R,4R,5R,6R)-5-[1-(4,5-Dimethoxy-2-nitro-phenyl)-2,2,2-trifluoro-ethoxy]-6-hydroxymethyl-2-p-tolyloxy-tetrahydro-pyran-3,4-diol

There total 3 articles about (2R,3R,4R,5R,6R)-5-[1-(4,5-Dimethoxy-2-nitro-phenyl)-2,2,2-trifluoro-ethoxy]-6-hydroxymethyl-2-p-tolyloxy-tetrahydro-pyran-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: Acetic acid (2R,3R,4S,5S,6R)-3-acetoxy-6-acetoxymethyl-5-[1-(4,5-dimethoxy-2-nitro-phenyl)-2,2,2-trifluoro-ethoxy]-2-p-tolyloxy-tetrahydro-pyran-4-yl ester

: 700362-47-6
(2R,3R,4R,5R,6R)-5-[1-(4,5-Dimethoxy-2-nitro-phenyl)-2,2,2-trifluoro-ethoxy]-6-hydroxymethyl-2-p-tolyloxy-tetrahydro-pyran-3,4-diol

Guidance literature:: With sodium methylate; In methanol; at 0 ℃; for 20h;
DOI:10.1002/anie.200353247

Reference yield:

: 700362-33-0
1-(4,5-dimethoxy-2-nitrophenyl)-2,2,2-trifluoroethan-1-ol

: 700362-47-6
(2R,3R,4R,5R,6R)-5-[1-(4,5-Dimethoxy-2-nitro-phenyl)-2,2,2-trifluoro-ethoxy]-6-hydroxymethyl-2-p-tolyloxy-tetrahydro-pyran-3,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 7 percent / TMAD; PBu₃ / benzene / 24 h / 70 °C

2: 92 percent / MeONa / methanol / 20 h / 0 °C

With tributylphosphine; diamide; sodium methylate; In methanol; benzene; 1: Mitsunobu reaction;
DOI:10.1002/anie.200353247

Reference yield:

: (p-methylphenyl)-2,3,6-tri-O-acetyl-α-D-glucopyranoside

: 700362-47-6
(2R,3R,4R,5R,6R)-5-[1-(4,5-Dimethoxy-2-nitro-phenyl)-2,2,2-trifluoro-ethoxy]-6-hydroxymethyl-2-p-tolyloxy-tetrahydro-pyran-3,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 7 percent / TMAD; PBu₃ / benzene / 24 h / 70 °C

2: 92 percent / MeONa / methanol / 20 h / 0 °C

With tributylphosphine; diamide; sodium methylate; In methanol; benzene; 1: Mitsunobu reaction;
DOI:10.1002/anie.200353247