Chemical Property of Pentamidine isethionate
Chemical Property:
- Appearance/Colour:COA
- Melting Point:188-194 °C(lit.)
- Boiling Point:539.4 °C at 760 mmHg
- Flash Point:280 °C
- PSA：284.16000
- LogP:4.37750
- Storage Temp.:−20°C
- Solubility.:Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
- Hydrogen Bond Donor Count:8
- Hydrogen Bond Acceptor Count:12
- Rotatable Bond Count:14
- Exact Mass:592.18728571
- Heavy Atom Count:39
- Complexity:493
- Purity/Quality:
-
99% *data from raw suppliers
Pentamidine isethionate *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38-43
- Safety Statements:
26-36/37
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Other Uses -> Pharmaceuticals
- Canonical SMILES:C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N.C(CS(=O)(=O)O)O.C(CS(=O)(=O)O)O
- Recent ClinicalTrials:Hypertrophic Scar Prevention by Novel Topical Gel Application
- Recent EU Clinical Trials:A Phase IIa Exploratory Study of OCZ103-OS in Combination with Platinum-Gemcitabine based Doublet First Line Therapy in Stage IV Non-Small Cell Lung Cancer (NSCLC) Patients
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Uses
Pentamidine isethionate salt has been used:as a positive control for anti-leishmanial, anti-plasmodial and cytotoxic assaysas a prototypical compound to analyse the inhibitor effect on human ether-a-go-go-related gene (HERG) K+ channel traffickingas an anti-leishmanial agent in promastigotes Antiparasitic
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Therapeutic Function
Antiprotozoal
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Clinical Use
4,4’-(Pentamethylenedioxy)dibenzamidine diisethionate(NebuPent, Pentam 300) is a water-soluble crystalline saltthat is stable to light and air. The principal use of pentamidineis for the treatment of pneumonia caused by the opportunisticpathogenic protozoan P. carinii, a frequent secondaryinvader associated with AIDS. The drug may beadministered by slow intravenous infusion or by deep intramuscularinjection for PCP. An aerosol form of pentamidineis used by inhalation for the prevention of PCP inhigh-risk patients infected with HIV who have a previoushistory of PCP infection or a low peripheral CD4+ lymphocytecount.Pentamidine has been used for the prophylaxis and treatmentof African trypanosomiasis. It also has some value fortreating visceral leishmaniasis. Pentamidine rapidly disappearsfrom the plasma after intravenous injection and is distributedto the tissues, where it is stored for a long period.This property probably contributes to the usefulness of thedrug as a prophylactic agent.
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Drug interactions
Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of ventricular
arrhythmias with amiodarone - avoid; possible
increased risk of ventricular arrhythmias with
disopyramide.
Antibacterials: increased risk of ventricular
arrhythmias with delamanid, moxifloxacin and
parenteral erythromycin - avoid with moxifloxacin;
increased risk of ventricular arrhythmias with
parenteral pentamidine and telithromycin.
Antidepressants: increased risk of ventricular
arrhythmias with tricyclics; increased risk of
ventricular arrhythmias with citalopram and
escitalopram - avoid.
Antimalarials: increased risk of ventricular
arrhythmias with piperaquine with artenimol -
avoid.
Antipsychotics: increased risk of ventricular
arrhythmias with amisulpride, droperidol and
phenothiazines - avoid with amisulpride and
droperidol.
Antivirals: increased risk of hypocalcaemia with
parenteral pentamidine and foscarnet; increased risk
of ventricular arrhythmias with saquinavir - avoid.
Cytotoxics: increased risk of ventricular arrhythmias
with vandetanib - avoid.
Ivabradine: increased risk of ventricular arrhythmias.
