(S)-N-(1-((6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)amino)-4-methyl-1-oxopentan-2-yl)picolinamide

Base Information

Chemical Name:(S)-N-(1-((6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)amino)-4-methyl-1-oxopentan-2-yl)picolinamide
CAS No.:1383708-63-1
Molecular Formula:C₂₉H₂₇FN₄O₃
Molecular Weight:498.557
Hs Code.:

Synonyms:(S)-N-(1-((6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)amino)-4-methyl-1-oxopentan-2-yl)picolinamide

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Chemical Property of (S)-N-(1-((6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)amino)-4-methyl-1-oxopentan-2-yl)picolinamide

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Technology Process of (S)-N-(1-((6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)amino)-4-methyl-1-oxopentan-2-yl)picolinamide

There total 4 articles about (S)-N-(1-((6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)amino)-4-methyl-1-oxopentan-2-yl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383709-53-2
C₂HF₃O₂*C₂₃H₂₄FN₃O₂

: picolinoyl chloride hydrochloride

: 1383708-63-1
(S)-N-(1-((6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)amino)-4-methyl-1-oxopentan-2-yl)picolinamide

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 1355052-34-4
2-(4-(4-fluorophenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1383708-63-1
(S)-N-(1-((6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)amino)-4-methyl-1-oxopentan-2-yl)picolinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 4 h / Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C

2.2: 12 h / 20 °C

3.1: dichloromethane / 1 h / 20 °C

4.1: sodium hydrogencarbonate / dichloromethane

With sodium hydrogencarbonate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1383709-51-0
C₂₈H₃₂FN₃O₄

: 1383708-63-1
(S)-N-(1-((6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)amino)-4-methyl-1-oxopentan-2-yl)picolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 1 h / 20 °C

2: sodium hydrogencarbonate / dichloromethane

With sodium hydrogencarbonate; In dichloromethane;