4-(4-fluorophenyl)-2-(1-methylethyl)-9-methyl-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine-3-carboxaldehyde

Base Information

• Chemical Name: 4-(4-fluorophenyl)-2-(1-methylethyl)-9-methyl-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine-3-carboxaldehyde
• CAS No.: 853182-49-7
• Molecular Formula: C₂₀H₂₁FN₂O₂
• Molecular Weight: 340.397

Synonyms:4-(4-fluorophenyl)-2-(1-methylethyl)-9-methyl-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine-3-carboxaldehyde

Chemical Property of 4-(4-fluorophenyl)-2-(1-methylethyl)-9-methyl-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine-3-carboxaldehyde

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Technology Process of 4-(4-fluorophenyl)-2-(1-methylethyl)-9-methyl-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine-3-carboxaldehyde

There total 1 articles about 4-(4-fluorophenyl)-2-(1-methylethyl)-9-methyl-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine-3-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-(4-fluorophenyl)-3-(hydroxymethyl)-2-(1-methylethyl)-9-methyl-6,7-dihydro-5H-pyrido[2,3-b]azepin-8(9H)-one (853182-47-5) → 4-(4-fluorophenyl)-2-(1-methylethyl)-9-methyl-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine-3-carboxaldehyde (853182-49-7)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.75h;

Reference yield: 99.0%

[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester (380460-37-7) + 4-(4-fluorophenyl)-2-(1-methylethyl)-9-methyl-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine-3-carboxaldehyde (853182-49-7) → 1,1-dimethylethyl2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-2-(1-methylethyl)-9-methyl-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl)ethenyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (853182-51-1)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.16667h;

upstream raw materials:

4-(4-fluorophenyl)-3-(hydroxymethyl)-2-(1-methylethyl)-9-methyl-6,7-dihydro-5H-pyrido[2,3-b]azepin-8(9H)-one

Downstream raw materials:

1,1-dimethylethyl2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-2-(1-methylethyl)-9-methyl-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl)ethenyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

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