((2R,3S)-6-(benzyloxy)-1-bromo-2-methylhexan-3-yloxy)(tert-butyl)dimethylsilane

Base Information

Chemical Name:((2R,3S)-6-(benzyloxy)-1-bromo-2-methylhexan-3-yloxy)(tert-butyl)dimethylsilane
CAS No.:1438887-87-6
Molecular Formula:C₂₀H₃₅BrO₂Si
Molecular Weight:415.486
Hs Code.:

Synonyms:((2R,3S)-6-(benzyloxy)-1-bromo-2-methylhexan-3-yloxy)(tert-butyl)dimethylsilane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((2R,3S)-6-(benzyloxy)-1-bromo-2-methylhexan-3-yloxy)(tert-butyl)dimethylsilane

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Technology Process of ((2R,3S)-6-(benzyloxy)-1-bromo-2-methylhexan-3-yloxy)(tert-butyl)dimethylsilane

There total 5 articles about ((2R,3S)-6-(benzyloxy)-1-bromo-2-methylhexan-3-yloxy)(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1438887-86-5
(2S,3S)-6-(benzyloxy)-3-(tert-butyldimethylsilyoxy)-2-methylhaxan-1-ol

: 1438887-87-6
((2R,3S)-6-(benzyloxy)-1-bromo-2-methylhexan-3-yloxy)(tert-butyl)dimethylsilane

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In acetonitrile; at 0 - 20 ℃; for 2.083h;
DOI:10.1016/j.tetlet.2013.01.134

Reference yield:

: 5470-84-8
4-benzyloxybutanal

: 1438887-87-6
((2R,3S)-6-(benzyloxy)-1-bromo-2-methylhexan-3-yloxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium tetrachloride / dichloromethane / -15 °C

1.2: 0.5 h / -15 °C

1.3: 1 h / -15 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

3.1: sodium tetrahydroborate; methanol / 1 h

4.1: triphenylphosphine; carbon tetrabromide / acetonitrile / 2.08 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; carbon tetrabromide; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; acetonitrile;
DOI:10.1016/j.tetlet.2013.01.134

Reference yield:

: 4541-14-4
4-benzyloxy-butan-1-ol

: 1438887-87-6
((2R,3S)-6-(benzyloxy)-1-bromo-2-methylhexan-3-yloxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

1.2: 1.5 h / -78 - 20 °C

2.1: titanium tetrachloride / dichloromethane / -15 °C

2.2: 0.5 h / -15 °C

2.3: 1 h / -15 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

4.1: sodium tetrahydroborate; methanol / 1 h

5.1: triphenylphosphine; carbon tetrabromide / acetonitrile / 2.08 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; oxalyl dichloride; carbon tetrabromide; titanium tetrachloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; acetonitrile;
DOI:10.1016/j.tetlet.2013.01.134