Technology Process of ER-848957-00
There total 10 articles about ER-848957-00 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ER-848947-00;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
for 0.416667h;
Cooling with ice;
2-Bromoethyl methyl ether;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: water; methanol / 72 h / 20 °C / Sealed tube
2.1: potassium carbonate / acetone / Reflux
3.1: hydrogenchloride / isopropyl alcohol; methanol / 16 h / 20 °C
4.1: sodium hydroxide / methanol
5.1: tetrahydrofuran / 2 h / 0 - 35 °C / Inert atmosphere
5.2: 2 h
6.1: trifluorormethanesulfonic acid / water; methanol / 35 - 45 °C
6.2: 2 h / 20 °C
7.1: water; methanol / 24 h / 20 °C
8.1: sodium hydroxide; water / methanol / 1 h
9.1: triethylamine / dichloromethane / 20 °C
10.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.42 h / Cooling with ice
10.2: 20 °C
With
hydrogenchloride; trifluorormethanesulfonic acid; water; sodium hydride; potassium carbonate; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; mineral oil;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium carbonate / acetone / Reflux
2.1: hydrogenchloride / isopropyl alcohol; methanol / 16 h / 20 °C
3.1: sodium hydroxide / methanol
4.1: tetrahydrofuran / 2 h / 0 - 35 °C / Inert atmosphere
4.2: 2 h
5.1: trifluorormethanesulfonic acid / water; methanol / 35 - 45 °C
5.2: 2 h / 20 °C
6.1: water; methanol / 24 h / 20 °C
7.1: sodium hydroxide; water / methanol / 1 h
8.1: triethylamine / dichloromethane / 20 °C
9.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.42 h / Cooling with ice
9.2: 20 °C
With
hydrogenchloride; trifluorormethanesulfonic acid; water; sodium hydride; potassium carbonate; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; mineral oil;
