2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-methyl}-2-methylbutyric acid

Base Information

Chemical Name:2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-methyl}-2-methylbutyric acid
CAS No.:1455088-14-8
Molecular Formula:C₂₃H₂₁N₃O₅
Molecular Weight:419.437
Hs Code.:

Synonyms:2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-methyl}-2-methylbutyric acid

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Chemical Property of 2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-methyl}-2-methylbutyric acid

Chemical Property:

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Technology Process of 2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-methyl}-2-methylbutyric acid

There total 4 articles about 2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-methyl}-2-methylbutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455092-99-5
2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}-2-methylbutyric acid tert-butyl ester

: 1455088-14-8
2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-methyl}-2-methylbutyric acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1114-82-5
2-cyanobutyric acid tert-butyl ester

: 1455088-14-8
2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-methyl}-2-methylbutyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 24 h / 0 - 40 °C

2: hydrogen / ethanol / 16 h / 20 °C

3: methanol / 1 h / 140 °C / Microwave irradiation

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1455092-95-1
2-cyano-2-methylbutyric acid tert-butyl ester

: 1455088-14-8
2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-methyl}-2-methylbutyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / ethanol / 16 h / 20 °C

2: methanol / 1 h / 140 °C / Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With hydrogen; trifluoroacetic acid; In methanol; ethanol; dichloromethane;