(R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoic acid (S)-1-(phenyl)ethylamine

Base Information

Chemical Name:(R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoic acid (S)-1-(phenyl)ethylamine
CAS No.:1379612-08-4
Molecular Formula:C₈H₁₁N*C₁₇H₂₆O₅
Molecular Weight:431.572
Hs Code.:

Synonyms:(R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoic acid (S)-1-(phenyl)ethylamine

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Chemical Property of (R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoic acid (S)-1-(phenyl)ethylamine

Chemical Property:

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Technology Process of (R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoic acid (S)-1-(phenyl)ethylamine

There total 8 articles about (R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoic acid (S)-1-(phenyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 172900-71-9
(R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid

: 1379612-08-4
(R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoic acid (S)-1-(phenyl)ethylamine

Guidance literature:: In cyclohexane; acetonitrile; at 0 - 30 ℃; for 1.5h;

Reference yield:

: 172900-75-3
4-methoxy-3-(3-methoxypropoxy)benzaldehyde

: 1379612-08-4
(R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoic acid (S)-1-(phenyl)ethylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 30 °C

1.2: pH 2

2.1: phosphorus tribromide / dichloromethane / 2.17 h / 0 - 5 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere

3.2: -70 - 5 °C

4.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 30 °C

5.1: cyclohexane; acetonitrile / 1.5 h / 0 - 30 °C

With sodium tetrahydroborate; lithium hydroxide monohydrate; dihydrogen peroxide; phosphorus tribromide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; cyclohexane; water; acetonitrile;

Reference yield:

: (4'R)-3-methyl-1-(2'-oxo-4'-phenyloxazolidin-3'-yl)butan-1-one

: 1379612-08-4
(R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoic acid (S)-1-(phenyl)ethylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere

1.2: -70 - 5 °C

2.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 30 °C

3.1: cyclohexane; acetonitrile / 1.5 h / 0 - 30 °C

With lithium hydroxide monohydrate; dihydrogen peroxide; lithium hexamethyldisilazane; In tetrahydrofuran; cyclohexane; water; acetonitrile;