naphtho[2,3-d][1,3]dioxol-5-yl 6-iodo-2,3-dimethoxybenzoate

Base Information

• Chemical Name: naphtho[2,3-d][1,3]dioxol-5-yl 6-iodo-2,3-dimethoxybenzoate
• CAS No.: 205178-57-0
• Molecular Formula: C₂₀H₁₅IO₆
• Molecular Weight: 478.24
• Mol file: 205178-57-0.mol

Synonyms:naphtho[2,3-d][1,3]dioxol-5-yl 6-iodo-2,3-dimethoxybenzoate

Chemical Property of naphtho[2,3-d][1,3]dioxol-5-yl 6-iodo-2,3-dimethoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of naphtho[2,3-d][1,3]dioxol-5-yl 6-iodo-2,3-dimethoxybenzoate

There total 14 articles about naphtho[2,3-d][1,3]dioxol-5-yl 6-iodo-2,3-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,3-dimethoxybenzoic acid (1521-38-6) + Naphtho<2,3-d>-1,3-dioxole-5-ol (77784-64-6) → naphtho[2,3-d][1,3]dioxol-5-yl 6-iodo-2,3-dimethoxybenzoate (205178-57-0)

Guidance literature:

2,3-dimethoxybenzoic acid; With N-iodo-succinimide; trifluoroacetic acid; In acetonitrile; for 48h; Inert atmosphere; Reflux;

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

Naphtho<2,3-d>-1,3-dioxole-5-ol; With triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tet.2017.04.028

Reference yield: 57.0%

6-iodo-2,3-dimethoxybenzoic acid (56221-41-1) + Naphtho<2,3-d>-1,3-dioxole-5-ol (77784-64-6) → naphtho[2,3-d][1,3]dioxol-5-yl 6-iodo-2,3-dimethoxybenzoate (205178-57-0)

Guidance literature:

With trifluoroacetic anhydride;

DOI:10.3987/COM-97-S23

Reference yield:

2,3-dimethoxy-6-iodobenzoyl chloride (130260-29-6) + Naphtho<2,3-d>-1,3-dioxole-5-ol (77784-64-6) → naphtho[2,3-d][1,3]dioxol-5-yl 6-iodo-2,3-dimethoxybenzoate (205178-57-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 2.5h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tet.2014.01.002

upstream raw materials:

6-iodo-2,3-dimethoxybenzoic acid

Naphtho<2,3-d>-1,3-dioxole-5-ol

6,7-methylenedioxy-1-tetralone

6,7-dihydroxy-3,4-dihydro-1(2H)-naphthalenone