CID 18530234

Base Information

• Chemical Name: CID 18530234
• CAS No.: 51-40-1
• Molecular Formula: C8H11NO3^.C4H6O6
• Molecular Weight: 319.268
• Hs Code.: 2922210000
• European Community (EC) Number: 200-095-0
• Mol file: 51-40-1.mol

Synonyms:51-40-1;AKOS025401326;AC-10038

Chemical Property of CID 18530234

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 2.24E-21mmHg at 25°C
• Melting Point: 102-104 °C
• Boiling Point: 442.6 °C at 760 mmHg
• PKA: 8.64(at 25℃)
• Flash Point: 221.5 °C
• PSA: 201.77000
• LogP: -1.33240
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 5
• Exact Mass: 319.09033112
• Heavy Atom Count: 22
• Complexity: 276

Purity/Quality:

99% ^*data from raw suppliers

(-)-ArterenolBitartrateSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1C(CN)O)O)O.C(C(C(=O)O)O)(C(=O)O)O
• Isomeric SMILES: C1=CC(=C(C=C1[C@@H](CN)O)O)O.C(C(C(=O)O)O)(C(=O)O)O
• Recent EU Clinical Trials: Comparison of the efficacy of ephedrine versus norepinephrine in the treatment of hypotension occurring after induction of general anesthesia in patients with chronic renal failure: randomized double-blind pilot study
• Description: Norepinephrine hydrogen tartrate monohydrate, also known as L-Norepinephrine, consists of norepinephrine combined with hydrogen tartrate in a 1:1 ratio, with an additional water molecule in the crystal lattice. Norepinephrine, a synthetic phenylethylamine, mimics the actions of endogenous norepinephrine, serving as a neurotransmitter and hormone. Its chemical structure is similar to adrenaline (epinephrine), containing a phenylethylamine backbone with a hydroxyl group on the beta carbon.
• Uses and Mechanism of Action: Norepinephrine hydrogen tartrate is categorized as a sympathomimetic amine and a peripheral vasoconstrictor. It acts directly on alpha-adrenergic receptors of vascular smooth muscle, causing vasoconstriction and increasing blood pressure. It also stimulates the heart and dilates coronary arteries by activating beta-adrenergic receptors. When administered intravenously, norepinephrine hydrogen tartrate exerts its effects rapidly, with a short duration of action. It is used clinically as a peripheral vasoconstrictor and heart stimulator, particularly in cases of hypotension caused by conditions like septic shock, neurogenic shock, or drug-induced hypotension. It is also employed as an emergency measure to elevate blood pressure when other interventions fail.
• Production Methods: Chemical synthesis methods involve the combination of norepinephrine with hydrogen tartrate to form norepinephrine hydrogen tartrate.

Refernces

The Relative Reactivity of Methylmagnesium Chloride and Dimethylmagnesium

10.1021/ja01874a043

The study investigates the relative reactivities of methylmagnesium chloride and dimethylmagnesium, focusing on their interactions with various carbonyl compounds in different solvents. Methylmagnesium chloride and dimethylmagnesium are the primary reagents used, with dioxane and isoamyl ether serving as solvents. The researchers found that dimethylmagnesium exhibits a preference for reacting with hydroxyl groups over carbonyl groups, forming ene-diol magnesium salts and resulting in less reactivity toward carbonyl functions compared to methylmagnesium chloride. This was demonstrated through reactions with benzoin, acetophenone, desoxybenzoin, and diphenylacetophenone, where dimethylmagnesium showed lower yields and incomplete reactions. The study also highlights the influence of solvents on reaction outcomes and suggests that the presence of dioxane does not alter the reaction course significantly.

Synthesis of 3,5,6-trisubstituted α-pyrones from Baylis-Hillman adducts

10.1016/j.tetlet.2006.11.180

The research aims to develop an efficient and convenient method for synthesizing 3,5,6-trisubstituted a-pyrones, which are important synthetic intermediates and components of various biologically active natural products. The study starts from Baylis–Hillman adducts and involves sequential steps including the introduction of a ketone at the primary position, lactonization, and oxidation with PCC. Key chemicals used include Baylis–Hillman acetates, various ketone derivatives such as deoxybenzoin and acetophenone, t-BuOK for the initial reaction, NaOH for hydrolysis, TFAA for lactonization, and PCC for oxidation. The results show that the desired a-pyrones can be obtained in moderate yields (51–64%) from the lactone intermediates (4a–h), with the overall process being effective for a range of substrates. The study concludes that this method provides a facile route for the synthesis of these valuable compounds, expanding the utility of Baylis–Hillman adducts in heterocyclic chemistry.

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