Technology Process of (S)-tert-butyl 2,2,2-trifluoro-1-(2-((3-methoxyphenyl)ethynyl)phenyl)ethylcarbamate
There total 5 articles about (S)-tert-butyl 2,2,2-trifluoro-1-(2-((3-methoxyphenyl)ethynyl)phenyl)ethylcarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-ethynyl-3-methoxybenzene; (S)-tert-butyl [2,2,2-trifluoro-1-(2-iodophenyl)ethyl]carbamate;
With
bis-triphenylphosphine-palladium(II) chloride; triethylamine;
In
tetrahydrofuran;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
With
copper(l) iodide;
In
tetrahydrofuran;
for 6h;
Inert atmosphere;
Heating;
DOI:10.1021/ol3035142
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrabutylammonium acetate / tetrahydrofuran / -20 °C / Inert atmosphere
2.1: hydrogenchloride / 1,4-dioxane; methanol / 0.33 h / 20 °C / Inert atmosphere
3.1: potassium carbonate / 1,4-dioxane / 20 °C / Inert atmosphere
4.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
4.2: 6 h / Inert atmosphere; Heating
With
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; tetrabutylammonium acetate; potassium carbonate; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol;
4.2: |Sonogashira Cross-Coupling;
DOI:10.1021/ol3035142
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: titanium(IV) tetraethanolate / dichloromethane / 0.08 h / Inert atmosphere
1.2: 20 h / 20 °C / Inert atmosphere
2.1: tetrabutylammonium acetate / tetrahydrofuran / -20 °C / Inert atmosphere
3.1: hydrogenchloride / 1,4-dioxane; methanol / 0.33 h / 20 °C / Inert atmosphere
4.1: potassium carbonate / 1,4-dioxane / 20 °C / Inert atmosphere
5.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
5.2: 6 h / Inert atmosphere; Heating
With
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; titanium(IV) tetraethanolate; tetrabutylammonium acetate; potassium carbonate; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
5.2: |Sonogashira Cross-Coupling;
DOI:10.1021/ol3035142
