Trifluoro-methanesulfonic acid 1-benzenesulfonyl-2-(3,4-dimethoxy-phenyl)-6-methoxy-3-methyl-1H-indol-5-yl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid 1-benzenesulfonyl-2-(3,4-dimethoxy-phenyl)-6-methoxy-3-methyl-1H-indol-5-yl ester
CAS No.:185146-14-9
Molecular Formula:C₂₅H₂₂F₃NO₈S₂
Molecular Weight:585.579
Hs Code.:

Synonyms:Trifluoro-methanesulfonic acid 1-benzenesulfonyl-2-(3,4-dimethoxy-phenyl)-6-methoxy-3-methyl-1H-indol-5-yl ester

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Chemical Property of Trifluoro-methanesulfonic acid 1-benzenesulfonyl-2-(3,4-dimethoxy-phenyl)-6-methoxy-3-methyl-1H-indol-5-yl ester

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Technology Process of Trifluoro-methanesulfonic acid 1-benzenesulfonyl-2-(3,4-dimethoxy-phenyl)-6-methoxy-3-methyl-1H-indol-5-yl ester

There total 4 articles about Trifluoro-methanesulfonic acid 1-benzenesulfonyl-2-(3,4-dimethoxy-phenyl)-6-methoxy-3-methyl-1H-indol-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: Trifluoro-methanesulfonic acid (2S,3S)-1-benzenesulfonyl-2-(3,4-dimethoxy-phenyl)-6-methoxy-3-methyl-2,3-dihydro-1H-indol-5-yl ester

: 185146-14-9
Trifluoro-methanesulfonic acid 1-benzenesulfonyl-2-(3,4-dimethoxy-phenyl)-6-methoxy-3-methyl-1H-indol-5-yl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; at 70 ℃; for 24h;
DOI:10.1021/jo9617068

Reference yield:

: 62035-67-0
N-(3,4-dimethoxyphenyl)benzenesulfonamide

: 185146-14-9
Trifluoro-methanesulfonic acid 1-benzenesulfonyl-2-(3,4-dimethoxy-phenyl)-6-methoxy-3-methyl-1H-indol-5-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / ceric ammonium nitrate / H₂O; acetonitrile / 0.17 h

2: 89 percent / TiCl₄, Ti(i-PrO)4 / CH₂Cl₂ / -78 °C

3: 69 percent / pyridine; CH₂Cl₂ / 0.25 h / -78 °C

4: 70 percent / DDQ / benzene / 24 h / 70 °C

With titanium(IV) isopropylate; ammonium cerium(IV) nitrate; titanium tetrachloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In pyridine; dichloromethane; water; acetonitrile; benzene;
DOI:10.1021/jo9617068

Reference yield:

: 168648-79-1
N-(3-methoxy-4-oxo-2,5-cyclohexadien-1-ylidene)benzenesulfonamide

: 185146-14-9
Trifluoro-methanesulfonic acid 1-benzenesulfonyl-2-(3,4-dimethoxy-phenyl)-6-methoxy-3-methyl-1H-indol-5-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / TiCl₄, Ti(i-PrO)4 / CH₂Cl₂ / -78 °C

2: 69 percent / pyridine; CH₂Cl₂ / 0.25 h / -78 °C

3: 70 percent / DDQ / benzene / 24 h / 70 °C

With titanium(IV) isopropylate; titanium tetrachloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In pyridine; dichloromethane; benzene;
DOI:10.1021/jo9617068