N-(2-(1-acetyl-2-iodo-1H-indol-3-yl)ethyl)-N-benzylbut-2-ynamide

Base Information

• Chemical Name: N-(2-(1-acetyl-2-iodo-1H-indol-3-yl)ethyl)-N-benzylbut-2-ynamide
• CAS No.: 1294437-78-7
• Molecular Formula: C₂₃H₂₁IN₂O₂
• Molecular Weight: 484.336
• Mol file: 1294437-78-7.mol

Synonyms:N-(2-(1-acetyl-2-iodo-1H-indol-3-yl)ethyl)-N-benzylbut-2-ynamide

Chemical Property of N-(2-(1-acetyl-2-iodo-1H-indol-3-yl)ethyl)-N-benzylbut-2-ynamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(1-acetyl-2-iodo-1H-indol-3-yl)ethyl)-N-benzylbut-2-ynamide

There total 3 articles about N-(2-(1-acetyl-2-iodo-1H-indol-3-yl)ethyl)-N-benzylbut-2-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-(1-acetyl-1H-indol-3-yl)ethylbenzylcarbamate (1294437-85-6) → N-(2-(1-acetyl-2-iodo-1H-indol-3-yl)ethyl)-N-benzylbut-2-ynamide (1294437-78-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: mercury(II) trifluoroacetate / dichloromethane / 0.08 h / 20 °C

1.2: 1 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C

3.1: dichloromethane / 20 °C

With mercury(II) trifluoroacetate; trifluoroacetic acid; In dichloromethane;

DOI:10.1002/ejoc.201001669

Reference yield:

N-t-butyloxycarbonyl-N-(phenylmethyl)-1H-indole-3-ethanamine (371246-08-1) → N-(2-(1-acetyl-2-iodo-1H-indol-3-yl)ethyl)-N-benzylbut-2-ynamide (1294437-78-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 20 °C

2.1: mercury(II) trifluoroacetate / dichloromethane / 0.08 h / 20 °C

2.2: 1 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C

4.1: dichloromethane / 20 °C

With tetra(n-butyl)ammonium hydrogensulfate; mercury(II) trifluoroacetate; trifluoroacetic acid; sodium hydroxide; In dichloromethane;

DOI:10.1002/ejoc.201001669

Reference yield:

C19H19IN2O + 1-[(but-2-ynoyl)oxy]pyrrolidine-2,5-dione (74549-10-3) → N-(2-(1-acetyl-2-iodo-1H-indol-3-yl)ethyl)-N-benzylbut-2-ynamide (1294437-78-7)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1002/ejoc.201001669

upstream raw materials:

1-[(but-2-ynoyl)oxy]pyrrolidine-2,5-dione

tert-butyl 2-(1-acetyl-1H-indol-3-yl)ethylbenzylcarbamate

N-t-butyloxycarbonyl-N-(phenylmethyl)-1H-indole-3-ethanamine

Downstream raw materials:

(Z)-6-acetyl-3-benzyl-5-ethylidene-2,3,5,6-tetrahydroazocino[4,5-b]indol-4(1H)-one