(3aR,7S,7aR)-1-<(2S)-2-Benzyloxycarbonylamino-3-methyl-1-oxobutyl>-1,2,3,3a,5,6,7,7a-octahydro-7-hydroxypyrano<3,2-b>pyrrol-5-on

Base Information

Chemical Name:(3aR,7S,7aR)-1-<(2S)-2-Benzyloxycarbonylamino-3-methyl-1-oxobutyl>-1,2,3,3a,5,6,7,7a-octahydro-7-hydroxypyrano<3,2-b>pyrrol-5-on
CAS No.:107692-75-1
Molecular Formula:C₂₀H₂₆N₂O₆
Molecular Weight:390.436
Hs Code.:

Synonyms:(3aR,7S,7aR)-1-<(2S)-2-Benzyloxycarbonylamino-3-methyl-1-oxobutyl>-1,2,3,3a,5,6,7,7a-octahydro-7-hydroxypyrano<3,2-b>pyrrol-5-on

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Chemical Property of (3aR,7S,7aR)-1-<(2S)-2-Benzyloxycarbonylamino-3-methyl-1-oxobutyl>-1,2,3,3a,5,6,7,7a-octahydro-7-hydroxypyrano<3,2-b>pyrrol-5-on

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Technology Process of (3aR,7S,7aR)-1-<(2S)-2-Benzyloxycarbonylamino-3-methyl-1-oxobutyl>-1,2,3,3a,5,6,7,7a-octahydro-7-hydroxypyrano<3,2-b>pyrrol-5-on

There total 1 articles about (3aR,7S,7aR)-1-<(2S)-2-Benzyloxycarbonylamino-3-methyl-1-oxobutyl>-1,2,3,3a,5,6,7,7a-octahydro-7-hydroxypyrano<3,2-b>pyrrol-5-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10084-80-7
N^α-benzyloxycarbonyl-L-valine anhydride

: 87125-57-3,87172-71-2,131434-96-3
rac-(3aR^*,7S^*,7aR^*)-1-tert-Butyloxycarbonyl-1,2,3,3a,5,6,7,7a-octahydro-7-hydroxypyrano<3,2-b>pyrrol-5-on

: 107692-75-1
(3aR,7S,7aR)-1-<(2S)-2-Benzyloxycarbonylamino-3-methyl-1-oxobutyl>-1,2,3,3a,5,6,7,7a-octahydro-7-hydroxypyrano<3,2-b>pyrrol-5-on

: 107692-85-3
(3aS,7R,7aS)-1-<(2S)-2-Benzyloxycarbonylamino-3-methyl-1-oxobutyl>-1,2,3,3a,5,6,7,7a-octahydro-7-hydroxypyrano<3,2-b>pyrrol-5-on

Guidance literature:: With 4-methyl-morpholine; trifluoroacetic acid; Yield given. Multistep reaction. Yields of byproduct given; 2.) acetonitrile, -5 deg C, 12 h;
DOI:10.1002/jlac.198619860111

Reference yield: 94.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 107692-75-1
(3aR,7S,7aR)-1-<(2S)-2-Benzyloxycarbonylamino-3-methyl-1-oxobutyl>-1,2,3,3a,5,6,7,7a-octahydro-7-hydroxypyrano<3,2-b>pyrrol-5-on

: 107692-76-2,107724-12-9
(3aR,7S,7aR)-1-<(2S)-2-Benzyloxycarbonylamino-3-methyl-1-oxobutyl>-1,2,3,3a,5,6,7a-octahydro-7-(tetrahydropyran-2-yloxy)pyrano<3,2-b>pyrrol-5-on

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1002/jlac.198619860111

Reference yield:

: 107692-75-1
(3aR,7S,7aR)-1-<(2S)-2-Benzyloxycarbonylamino-3-methyl-1-oxobutyl>-1,2,3,3a,5,6,7,7a-octahydro-7-hydroxypyrano<3,2-b>pyrrol-5-on

: 37878-19-6
detoxin D&%1

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / toluene-4-sulphonic acid monohydrate / CH₂Cl₂ / 3 h / 20 °C

3: 87 percent / 4-(dimethylamino)pyridine / 1.) 2 h, -20 deg C, 2.) 12 h, 5 deg C

4: 1.) trifluoroacetic acid, 2.) N-methylmorpholine / 1.) 20 min, 0 deg C to room temp. 2.) methylene dichloride, 0 - 5 degC

5: 88 percent / H₂ / Pd/C / methanol

With 4-methyl-morpholine; dmap; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1002/jlac.198619860111