(2R,4aR,6S,9bR)-8-amino-4,4a,6,9b-tetrahydro-6-methoxy-2-phenylthieno[2',3':4,5]pyrano[3,2-d][1,3]dioxine-7-carbonitrile

Base Information

Chemical Name:(2R,4aR,6S,9bR)-8-amino-4,4a,6,9b-tetrahydro-6-methoxy-2-phenylthieno[2',3':4,5]pyrano[3,2-d][1,3]dioxine-7-carbonitrile
CAS No.:887480-51-5
Molecular Formula:C₁₇H₁₆N₂O₄S
Molecular Weight:344.391
Hs Code.:

Synonyms:(2R,4aR,6S,9bR)-8-amino-4,4a,6,9b-tetrahydro-6-methoxy-2-phenylthieno[2',3':4,5]pyrano[3,2-d][1,3]dioxine-7-carbonitrile

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Chemical Property of (2R,4aR,6S,9bR)-8-amino-4,4a,6,9b-tetrahydro-6-methoxy-2-phenylthieno[2',3':4,5]pyrano[3,2-d][1,3]dioxine-7-carbonitrile

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Technology Process of (2R,4aR,6S,9bR)-8-amino-4,4a,6,9b-tetrahydro-6-methoxy-2-phenylthieno[2',3':4,5]pyrano[3,2-d][1,3]dioxine-7-carbonitrile

There total 1 articles about (2R,4aR,6S,9bR)-8-amino-4,4a,6,9b-tetrahydro-6-methoxy-2-phenylthieno[2',3':4,5]pyrano[3,2-d][1,3]dioxine-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 164928-23-8
Methyl 4,6-O-benzylidene-2-(dicyanomethylene)-2,3-dideoxy-α-D-erythro-hexopyranoside

: 887480-51-5
(2R,4aR,6S,9bR)-8-amino-4,4a,6,9b-tetrahydro-6-methoxy-2-phenylthieno[2',3':4,5]pyrano[3,2-d][1,3]dioxine-7-carbonitrile

Guidance literature:: With sulfur; diethylamine; In methanol; at 45 ℃; for 2h;
DOI:10.1080/07328300500495852

Reference yield: 82.0%

: 887480-51-5
(2R,4aR,6S,9bR)-8-amino-4,4a,6,9b-tetrahydro-6-methoxy-2-phenylthieno[2',3':4,5]pyrano[3,2-d][1,3]dioxine-7-carbonitrile

: 122-51-0
orthoformic acid triethyl ester

: 887480-52-6
(2R,4aR,6S,9bR)-8-(aminomethylenamino)-4,4a,6,9b-tetrahydro-6-methoxy-2-phenylthieno[2',3':4,5]pyrano[3,2-d][1,3]dioxine-7-carbonitrile

Guidance literature:: (2R,4aR,6S,9bR)-8-amino-4,4a,6,9b-tetrahydro-6-methoxy-2-phenylthieno[2',3':4,5]pyrano[3,2-d][1,3]dioxine-7-carbonitrile; orthoformic acid triethyl ester; for 2h; Heating;

With ammonia; In ethanol; at 20 ℃;
DOI:10.1080/07328300500495852

Reference yield:

: 887480-51-5
(2R,4aR,6S,9bR)-8-amino-4,4a,6,9b-tetrahydro-6-methoxy-2-phenylthieno[2',3':4,5]pyrano[3,2-d][1,3]dioxine-7-carbonitrile

: (2R,4aR,6S,11bR)-4,4a,6,11b-tetrahydro-6-methoxy-2-phenyl-[1,3]dioxino[4'',5'':5',6']pyrano[3',4':4,5]thieno[2,3-d]pyrimidin-7-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2 h / Heating

1.2: 82 percent / ammonia / ethanol / 20 °C

2.1: 71 percent / sodium hydride / dimethylformamide / 1 h / 20 °C

With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1080/07328300500495852