3a-allyl-4-[(4-methylphenyl)sulfonyl]-2,3,3a,4,5,6-hexahydrocyclopenta[a][1,3]dioxolo[4,5-h][3]benzazepine

Base Information

Chemical Name:3a-allyl-4-[(4-methylphenyl)sulfonyl]-2,3,3a,4,5,6-hexahydrocyclopenta[a][1,3]dioxolo[4,5-h][3]benzazepine
CAS No.:916085-38-6
Molecular Formula:C₂₄H₂₅NO₄S
Molecular Weight:423.533
Hs Code.:

Synonyms:3a-allyl-4-[(4-methylphenyl)sulfonyl]-2,3,3a,4,5,6-hexahydrocyclopenta[a][1,3]dioxolo[4,5-h][3]benzazepine

Suppliers and Price of 3a-allyl-4-[(4-methylphenyl)sulfonyl]-2,3,3a,4,5,6-hexahydrocyclopenta[a][1,3]dioxolo[4,5-h][3]benzazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3a-allyl-4-[(4-methylphenyl)sulfonyl]-2,3,3a,4,5,6-hexahydrocyclopenta[a][1,3]dioxolo[4,5-h][3]benzazepine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3a-allyl-4-[(4-methylphenyl)sulfonyl]-2,3,3a,4,5,6-hexahydrocyclopenta[a][1,3]dioxolo[4,5-h][3]benzazepine

There total 10 articles about 3a-allyl-4-[(4-methylphenyl)sulfonyl]-2,3,3a,4,5,6-hexahydrocyclopenta[a][1,3]dioxolo[4,5-h][3]benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 916085-37-5
N-{1-allyl-2-[6-(2-hydroxy-ethyl)-1,3-benzodioxol-5-yl]-2-cyclopenten-1-yl}-4-methylbenzenesulfonamide

: 916085-38-6
3a-allyl-4-[(4-methylphenyl)sulfonyl]-2,3,3a,4,5,6-hexahydrocyclopenta[a][1,3]dioxolo[4,5-h][3]benzazepine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 20 ℃; for 14h;
DOI:10.1021/ol062073e

Reference yield:

: cis-5-allyl-6-[(4-methylphenyl)sulfonyl]-6-azabicyclo[3.1.0]hexan-2-ol

: 916085-38-6
3a-allyl-4-[(4-methylphenyl)sulfonyl]-2,3,3a,4,5,6-hexahydrocyclopenta[a][1,3]dioxolo[4,5-h][3]benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: KHMDS / tetrahydrofuran / 0.5 h / -78 °C

1.2: 93 percent / tetrahydrofuran / 17 h / -78 - 20 °C

2.1: n-BuLi / diethyl ether; hexane / 1 h / -78 °C

2.2: 43 percent / diethyl ether; hexane / 0.08 h / -78 °C

3.1: 100 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

4.1: 65 percent / PPh₃; DIAD / toluene / 14 h / 20 °C

With n-butyllithium; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; triphenylphosphine; In tetrahydrofuran; diethyl ether; hexane; toluene;
DOI:10.1021/ol062073e

Reference yield:

: 5-allyl-4-methoxy-6-[(4-methylphenyl)sulfonyl]-6-azabicyclo[3.1.0]pentane

: 916085-38-6
3a-allyl-4-[(4-methylphenyl)sulfonyl]-2,3,3a,4,5,6-hexahydrocyclopenta[a][1,3]dioxolo[4,5-h][3]benzazepine

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / diethyl ether; hexane / 1 h / -78 °C

1.2: 43 percent / diethyl ether; hexane / 0.08 h / -78 °C

2.1: 100 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

3.1: 65 percent / PPh₃; DIAD / toluene / 14 h / 20 °C

With n-butyllithium; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; diethyl ether; hexane; toluene;
DOI:10.1021/ol062073e